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Endotoxin and grain dust-induced lung inflammation.

Authors
Schwartz-DA; Jagielo-PJ; Bleuer-SA; Frees-K
Source
Toxicologist 1994 Mar; 14(1):88
NIOSHTIC No.
20035540
Abstract
Dose-response relationships were studied for inhaled grain dust extracts and endotoxin with bronchoalveolar lavage fluid (BALF) concentrations of total cells, neutrophils, and tumor necrosis factor-a (fNF). The inhalation model utilized C3H/HeJ mice that are unresponsive to endotoxin and C3H/HeBFFJ endotoxin responsive mice. Exposures were performed in groups of 12 (6 of each strain) for 4 hr. 20 groups of mice were exposed to aerosols of 0.1 % corn dust extract (CDE), filter sterilized CDE (SCDE), E. coli endotoxin (LPS), or saline. After exposure, lungs were lavaged and fixed for histological study. Endotoxin resistant mice were unresponsive to LPS and demonstrated only minor responses to CDE and SCDE at high doses. Endotoxin sensitive mice demonstrated significantly greater (p < 0.001) dose-dependent responses for CDE, SCDE, and LPS than the endotoxin resistant mice over a SOO-fold dose range. There were no significant within-strain differences for neutrophil and TNF-a responses upon exposure to these agents. Further, the endotoxin resistant mice demonstrated a blunted inflammatory response to both CDE and SCDE. These findings suggest that endotoxin may be a key agent in acute grain dust-induced lung inflammation.
Keywords
Lung-fibrosis; Lung-function; Mathematical-models; Statistical-analysis; Farmers; Dose-response; Laboratory-animals; Endotoxins
Contact
Internal Medicine University of Iowa Pulmonary Disease Division Iowa City, IA 52242
Publication Date
19940301
Document Type
Abstract
Funding Amount
122514
Funding Type
Grant; Cooperative Agreement
Fiscal Year
1994
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-000093; Cooperative-Agreement-Number-U07-CCU-706145
Issue of Publication
1
ISSN
0731-9193
Priority Area
Pulmonary System Disorders
Source Name
The Toxicologist. Society of Toxicology 33rd Annual Meeting, March 13-17, 1994, Dallas, Texas
State
IA
Performing Organization
University of Iowa, Iowa City, Iowa
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