Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

A nested case-control study of multiple myeloma risk and uranium exposure among workers at the Oak Ridge gaseous diffusion plant.

Authors
Yiin-JH; Anderson-JL; Daniels-RD; Seel-EA; Fleming-DA; Waters-KM; Chen-PH
Source
Radiat Res 2009 Jun; 171(6):637-645
NIOSHTIC No.
20035535
Abstract
The primary risk factors of multiple myeloma are age, race and sex, but several studies have found an association between radiological hazards and multiple myeloma. The purpose of this nested case-control study was to investigate whether workers with chronic low-level exposure to internally deposited uranium at the Oak Ridge Gaseous Diffusion Plant in eastern Tennessee were at higher risk of dying of multiple myeloma than those without occupational exposure to uranium, with the consideration of potential confounders of external ionizing radiation and occupational chemical hazards such as mercury, nickel and trichloroethylene. The main analyses were carried out using conditional logistic regression on 98 cases and 490 controls (five controls matched to each case on gender, race and age at risk). Our study showed a weak association between internal uranium dose estimated from urinalysis results and multiple myeloma risk: OR = 1.04 (95% CI 1.00-11.09) at 10 mu Gy with the inclusion of other risk factors. The parameter estimates and the corresponding odds ratios were very similar when internal doses were imputed for subjects without urine samples. Further studies that include updating this cohort and combining with workers from other gaseous diffusion plants are needed to investigate the relationship between multiple myeloma risk and radiation or other chemical exposures.
Keywords
Age-factors; Biological-factors; Cancer; Chemical-hypersensitivity; Chemical-properties; Chemical-reactions; Exposure-levels; Exposure-limits; Exposure-methods; Ionization; Ionizing-radiation; Nuclear-radiation; Occupational-exposure; Occupational-hazards; Racial-factors; Radiation-effects; Radiation-exposure; Radiation-hazards; Radiation-injury; Radiation-levels; Radiation-properties; Radiation-sources; Sex-factors; Skin-cancer; Skin-diseases; Statistical-analysis; Work-environment; Work-operations; Worker-health; Workplace-studies
Contact
JH Yiin, NIOSH, DSHEFS, 4676 Columbia Pakway, MS R-15, Cincinnati, OH 45226
CODEN
RAREAE
CAS No.
7439-97-6; 7440-02-0; 79-01-6
Publication Date
20090601
Document Type
Journal Article
Email Address
JYiin@cdc.gov
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
0033-7587
NIOSH Division
DSHEFS
Source Name
Radiation Research
State
OH
TOP