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Population variation in glial fibrillary acidic protein levels in brain ageing: relationship to alzheimer-type pathology and dementia.

Authors
Wharton-SB; O'Callaghan-JP; Sawa-GM; Nicoll-JAR; Matthews-F; Simpson-JE; Forster-G; Shaw-PJ; Brayne-C; Ince-PG
Source
Dement Geriatr Cogn Disord 2009 Jun; 27(5):465-473
NIOSHTIC No.
20035478
Abstract
Background: The cellular pathology of astrocytes in brain ageing and their role in modulating the brain's response to neurodegenerative pathology remain incompletely understood. Methods: Using quantitative ELISA, we have investigated glial fibrillary acidic protein (GFAP) expression in the population-based neuropathology cohort of the Medical Research Council Cognitive Function and Ageing Study to determine: (1) the population variation in the astroglial hypertrophic response, (2) its relationship to the presence of Alzheimer-type pathology, and (3) its association with cognition. Results: Increasing GFAP was found with increasing Braak stage, levels increasing even at early stages. Within Braak stages, GFAP did not differ between demented and non-demented individuals, but there was greater variance in GFAP in the demented. Possession of Apo e4 was associated with slightly increased GFAP levels (not significant) for given amyloid protein loads. Conclusion: In a population-based sample, increasing gliosis precedes development of Alzheimer lesions. Population variation in GFAP with varying Alzheimer lesion burdens suggests that they are not the only driver for astrogliosis. GFAP was not independently predictive of dementia, but the variation in astrocytic responses may be a factor modulating brain responses to neurodegenerative pathology.
Keywords
Age-factors; Age-groups; Brain-disorders; Brain-function; Neurological-system; Neuropathology; Psychological-disorders Psychological-factors; Psychological-testing; Quantitative-analysis; Author Keywords: Glial fibrillary acidic protein; Gliosis; Astrogliosis; Astrocyte pathology; Alzheimers disease; Brain ageing
Contact
S.B. Wharton Academic Unit of Pathology, University of Sheffield Medical School Beech Hill Road Sheffield, S10 2RX (UK)
CODEN
DGCDFX
Publication Date
20090601
Document Type
Journal Article
Email Address
s.wharton@sheffield.ac.uk
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
1420-8008
NIOSH Division
HELD
Source Name
Dementia and Geriatric Cognitive Disorders
State
WV
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