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Numerical simulations investigating the regional and overall deposition efficiency of the human nasal cavity.

Authors
Shanley-KT; Zamankhan-P; Ahmadi-G; Hopke-PK; Cheng-YS
Source
Inhal Toxicol 2008 Sep; 20(12):1093-1100
NIOSHTIC No.
20035420
Abstract
Numerical simulations have been carried out on a model of the right passageway of an anonymous, adult male's nasal cavity, constructed from magnetic resonance imagery (MRI) scans. Steady, laminar, inspiratory flow was assumed to simulate inhalation. Analysis shows smoothly varying streamlines with a peak in velocity magnitude occurring in the nasal valves and a peak in vorticity magnitude immediately posterior. Dilute, uniform concentrations of inertial (1 microm < or = d(ae) < or = 10 microm) particles were released at the nostril and tracked via a Lagrangian tracking algorithm. Deposition efficiency is shown to increase with particle size and flow rate. Preferential deposition is seen in the anterior third of the nasal cavity for large Stokes number particles. An empirical expression for particle deposition is proposed that incorporates particle size, flow rate, and nose anatomy.
Keywords
Aerosol-particles; Aerosols; Air-contamination; Air-flow; Air-monitoring; Air-quality; Air-sampling; Air-sampling-techniques; Breathing; Ergonomics; Fibrous-dusts; Inhalation-studies; Laboratory-techniques; Laboratory-testing; Mathematical-models; Models; Nasal-cavity; Nasal-disorders; Particle-aerodynamics; Particle-counters; Particulate-dust; Particulate-sampling-methods; Posture; Qualitative-analysis; Respirable-dust; Respiration; Respiratory-function-tests; Respiratory-hypersensitivity; Respiratory-irritants; Statistical-analysis
Contact
Prof. Goodarz Ahmadi, Clarkson University, Department of Mechanical and Aeronautical Engineering, 8 Clarkson Avenue, Potsdam, NY 13699-5700,
CODEN
INHTE5
Publication Date
20080901
Document Type
Journal Article
Email Address
ahmadi@clarkson.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003900
Issue of Publication
12
ISSN
0895-8378
Source Name
Inhalation Toxicology
State
NM
Performing Organization
Lovelace Biomedical & Environmental Research
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