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Immunotoxicogenomics: gene expression and immunotoxicology in the age of genomics.

Authors
Germolec-DR; Burns-Naas-LA; Gerberick-GF; Ladics-GS; Ryan-CA; Pruett-SB; Yucesoy-B; Luebke-RW
Source
Genomics: fundamentals and applications. Choudhuri S, Carlson DB, eds. New York: Informa HealthCare, 2008 Oct; :247-268
Link
NIOSHTIC No.
20035365
Abstract
For the near future, genomic arrays are likely to continue to play a role in identifying modes or mechanisms of action and the biochemical pathways that are altered following chemical exposure rather than supplying data appropriate for hazard identification and risk assessment. Additional studies addressing specificity, sensitivity, and reproducibility are needed to determine whether any of the molecular changes observed at a particular time and dose of chemical are predictive of toxicological effects observed in vivo or in vitro . There is no doubt, however, that further development, evaluation, and implementation of gene array technology have the potential to reduce animal usage and ultimately reduce the cost of conducting toxicology studies in general.
Keywords
Immune-reaction; Immunological-tests; Immunology; Immunotoxins; Genes; Gene-mutation; Risk-analysis; Analytical-processes; Toxic-effects; Toxicopathology
Publication Date
20090101
Document Type
Book or book chapter
Editors
Choudhuri-S; Carlson-DB
Fiscal Year
2009
NTIS Accession No.
NTIS Price
ISBN No.
9781420067057
NIOSH Division
HELD
Priority Area
Healthcare and Social Assistance; Services
Source Name
Genomics: fundamentals and applications
State
WV
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