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Overexpression of the erbB-2 proto-oncogene in canine osteosarcoma cell lines and tumors.

Authors
Flint-AF; U'Ren-L; Legare-ME; Withrow-SJ; Dernell-W; Hanneman-WH
Source
Vet Pathol 2004 May; 41(3):291-296
NIOSHTIC No.
20035332
Abstract
The status of the erbB-2 (human epidermal growth factor receptor 2/neu) proto-oncogene in canine osteosarcoma (OSA) has not been reported previously. In this study we used real-time reverse transcriptase polymerase chain reaction to evaluate erbB-2 expression in seven canine OSA cell lines and 10 canine OSA tissue samples. We determined erbB-2 to be significantly overexpressed in 86% (six of seven) of the cell lines and 40% (4 of 10) of the OSA tissues samples. Given the importance of erbB-2 in human breast cancer, the finding of erbB-2 overexpression in canine OSA may be important in further understanding the pathogenesis and possible therapies of OSA.
Keywords
Animal-studies; Animals; Chemical-reactions; Chemical-synthesis; Cancer; Cancer-rates; Pathogenesis; Pathogenicity; Pathogens; Growth-disorders; Growth-factors; Growth-inhibition; Growth-inhibitors; Oncogenesis; Oncogenic-agents; Oncogenicity; Bone-cancer; Bone-disorders; Bone-structure; Exposure-levels; Exposure-limits; Exposure-methods; Author Keywords: Canine model; dogs; erbB-2; HER2; osteosarcoma
Contact
A. F. Flint, Department of Environmental and Radiological Health Sciences, College of Veterinary Medicine and Biomedical Sciences, Colorado State University, Campus Delivery, Building Physiology 1680, Fort Collins, CO 80523
CODEN
VTPHAK
Publication Date
20040501
Document Type
Journal Article
Email Address
hanneman@colostate.edu
Funding Type
Agriculture; Cooperative Agreement
Fiscal Year
2004
NTIS Accession No.
NTIS Price
Identifying No.
Cooperative-Agreement-Number-U50-OH-007545
Issue of Publication
3
ISSN
0300-9858
Source Name
Veterinary Pathology
State
CO
Performing Organization
Colorado State University - Fort Collins
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