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Association of cumulative lead and neurocognitive function in an occupational cohort.

Authors
Khalil-N; Morrow-LA; Needleman-H; Talbott-EO; Wilson-JW; Cauley-JA
Source
Neuropsychology 2009 Jan; 23(1):10-19
NIOSHTIC No.
20035279
Abstract
Lead is a neurotoxicant that accumulates in bone with a half life of 25-30 years. To evaluate the association of lead biomarkers and cognitive function, a cohort of exposed and nonexposed workers who had been previously assessed in 1982 was retested approximately 22 years later. For the current assessment, both blood lead and tibia bone lead levels were determined. In addition, cognitive function was tested with the Pittsburgh Occupational Exposures Test battery, which had previously been administered in 1982. In exposed workers, bone lead level predicted lower current cognitive performance and cognitive decline over 22 years. In those lead-exposed workers older than age 55, higher levels of bone lead predicted poorer cognitive scores, suggesting vulnerability for older workers with higher past lead exposure. Finally, there was no association with bone lead level and recency of exposure, suggesting that cumulative body burden is most likely responsible for the progressive cognitive decrement evidenced with vulnerability because of aging.
Keywords
Age-factors; Biologic-half-life; Biological-effects; Biological-monitoring; Biomarkers; Bone-disorders; Demographic-characteristics; Epidemiology; Exposure-assessment; Exposure-levels; Lead-compounds; Metal-compounds; Metals; Neuropathology; Psychophysiology; Skeletal-system-disorders
Contact
Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA
CODEN
NEUPEG
CAS No.
7439-92-1
Publication Date
20090101
Document Type
Journal Article
Funding Amount
1010879
Funding Type
Grant
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003891
Issue of Publication
1
ISSN
0894-4105
Priority Area
Work Environment and Workforce: Special Populations
Source Name
Neuropsychology
State
PA
Performing Organization
University of Pittsburgh, Pittsburgh, Pennsylvania
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