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Positive associations between ionizing radiation and lymphoma mortality among men.

Authors
Richardson-DB; Sugiyama-H; Wing-S; Sakata-R; Grant-E; Shimizu-Y; Nishi-N; Geyer-S; Soda-M; Suyama-A; Kasagi-F; Kodama-K
Source
Am J Epidemiol 2009 Apr; 169(8):969-976
NIOSHTIC No.
20035215
Abstract
The authors investigated the relation between ionizing radiation and lymphoma mortality in 2 cohorts: 1) 20,940 men in the Life Span Study, a study of Japanese atomic bomb survivors who were aged 15-64 years at the time of the bombings of Hiroshima and Nagasaki, and 2) 15,264 male nuclear weapons workers who were hired at the Savannah River Site in South Carolina between 1950 and 1986. Radiation dose-mortality trends were evaluated for all malignant lymphomas and for non-Hodgkin's lymphoma. Positive associations between lymphoma mortality and radiation dose under a 5-year lag assumption were observed in both cohorts (excess relative rates per sievert were 0.79 (90% confidence interval: 0.10, 1.88) and 6.99 (90% confidence interval: 0.96, 18.39), respectively). Exclusion of deaths due to Hodgkin's disease led to small changes in the estimates of association. In each cohort, evidence of a dose-response association was primarily observed more than 35 years after irradiation. These findings suggest a protracted induction and latency period for radiation-induced lymphoma mortality.
Keywords
Mortality-data; Mortality-rates; Cancer; Cancer-rates; Epidemiology; Occupational-diseases; Risk-analysis; Radiation-therapy; Lymphocytes; Lymphatic-cancer; Lymphatic-system-disorders; Statistical-analysis; Author Keywords: lymphoma; mortality; nuclear weapons; radiation; ionizing
Contact
David B. Richardson, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599-7435
CODEN
AJEPAS
Publication Date
20090415
Document Type
Journal Article
Email Address
david.richardson@unc.edu
Funding Type
Grant
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007871
Issue of Publication
8
ISSN
0002-9262
Priority Area
Research Tools and Approaches: Cancer Research Methods
Source Name
American Journal of Epidemiology
State
NC
Performing Organization
University of North Carolina at Chapel Hill, Chapel Hill, North Carolina
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