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Rat- and human-based risk estimates of lung cancer from occupational exposure to poorly-soluble particles: a quantitative evaluation.

Authors
Kuempel-ED; Smith-RJ; Dankovic-DA; Stayner-LT
Source
J Phys: Conf Ser, Inhaled Particles X 2009 Mar; 151(1):012011
NIOSHTIC No.
20035183
Abstract
In risk assessment there is a need for quantitative evaluation of the capability of animal models to predict disease risks in humans. In this paper, we compare the rat- and human-based excess risk estimates for lung cancer from working lifetime exposures to inhaled poorly-soluble particles. The particles evaluated include those for which long-term dose-response data are available in both species, i.e., coal dust, carbon black, titanium dioxide, silica, and diesel exhaust particulate. The excess risk estimates derived from the rat data were generally lower than those derived from the human studies, and none of the rat- and human-based risk estimates were significantly different (all p-values>0.05). Residual uncertainty in whether the rat-based risk estimates would over- or under-predict the true excess risks of lung cancer from inhaled poorly-soluble particles in humans is due in part to the low power of the available human studies, limited particle size exposure data for humans, and ambiguity about the best animal models and extrapolation methods.
Keywords
Biodynamics; Biohazards; Biological-effects; Biological-factors; Biological-transport; Breathing; Breathing-zone; Cell-biology; Cell-damage; Cell-metabolism; Cellular-reactions; Chronic-exposure; Diesel-emissions; Dose-response; Health-hazards; Humans; Inhalation-studies; Laboratory-animals; Lung-cancer; Lung-disease; Lung-disorders; Mathematical-models; Pulmonary-cancer; Particle-aerodynamics; Particulate-sampling-methods; Pulmonary-congestion; Pulmonary-disorders; Pulmonary-function; Pulmonary-system-disorders; Risk-analysis; Statistical-analysis
Contact
Eileen Kumpel, CDC, NIOSH, EID, Risk Evaluation Branch, 4676 Columbia Parkway, Cincinnati, OH 45226
CAS No.
1333-86-4; 13463-67-7; 7631-86-9
Publication Date
20090313
Document Type
Journal Article; Academic/Scholarly
Email Address
ekuempel@cdc.gov
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
1742-6596
NIOSH Division
EID
Priority Area
Manufacturing; Mining
Source Name
Journal of Physics: Conference Series, Inhaled Particles X, 23-25 September 2008, Sheffield, UK
State
OH
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