Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Blood lead, serum homocysteine, and neurobehavioral test performance in the third National Health and Nutrition Examination Survey.

Authors
Krieg-EF Jr.; Butler-MA
Source
Neurotoxicology 2009 Mar; 30(2):281-289
NIOSHTIC No.
20035166
Abstract
Regression analysis was used to estimate and test for relationships between blood lead, serum folate, red blood cell folate, serum vitamin B12, serum homocysteine, and neurobehavioral test performance in adults, 20-59 years old, participating in the third National Health and Nutrition Examination Survey. The three neurobehavioral tests included in the survey were simple reaction time, symbol-digit substitution, and serial digit learning. Serum folate, red blood cell folate, and serum vitamin B12 decreased as the blood lead concentration increased. Serum homocysteine increased as the blood lead concentration increased. Serum homocysteine decreased as the serum folate and serum vitamin B12 concentrations increased. Neurobehavioral test performance was not related to the blood lead, serum folate, or serum vitamin B12 concentrations. In adults 20-39 years old, performance on the serial digit learning test improved as the serum homocysteine concentration increased. In adults 40-59 years old, neurobehavioral test performance was not related to the serum homocysteine concentration. Homocysteine may impair cognitive function by acting at N-methyl-D-aspartate receptors, and improve cognitive function by acting at N-methyl-D-aspartate or gamma-aminobutyric acid receptors.
Keywords
Age-factors; Age-groups; Biochemistry; Biodynamics; Biological-function; Biological-transport; Blood-serum; Blood-cells; Blood-analysis; Iron-compounds; Brain-function; Chemical-reactions; Lead-compounds; Neurological-reactions; Neurological-system; Neuromotor-function; Neuromotor-system; Neurophysiological-effects; Neurotransmitters; Reaction-rates; Author Keywords: Blood lead; Folate; Vitamin B12; Homocysteine; Neurobehavioral tests; NHANES III; NMDA; GABA
Contact
Centers for Disease Control and Prevention, National Institute for Occupational Safety and Health, Division of Applied Research & Technolo, MS C22, Robert A. Taft Laboratories, 4676 Columbia Parkway, Cincinnati, OH 45226-1998
CODEN
NRTXDN
Publication Date
20090301
Document Type
Journal Article
Email Address
erk3@cdc.gov
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0161-813X
NIOSH Division
DART
Source Name
Neurotoxicology
State
OH
TOP