Issues in the development of epidemiologic studies of workers exposed to engineered nanoparticles.
Schulte-PA; Schubauer-Berigan-MK; Mayweather-C; Geraci-CL; Zumwalde-R; McKernan-JL
J Occup Environ Med 2009 Mar; 51(3):323-335
Objective: Capitalizing on phenomena at the nanoscale may present great benefits to society. Nevertheless, until the hazards and risks of engineered nanoparticles are determined, the technological products and advances of nanotechnology may be impeded by the societal concerns. Although animal data provide the necessary first step in hazard and risk assessment, ultimately epidemiological studies will be required, especially studies of workers exposed to engineered, nanoparticles. It. may be too soon to conduct informative epidemiological studies but it is now appropriate to identify issues that, will be pertinent and prepare strategies to address them. Methods: The published scientific literature on incidental and engineered nanoparticles and air pollution were reviewed to identify issues in the conduct of epidemiological studies of workers exposed to engineered nanoparticles. Results: Twelve important issues were identified-the most critical pertaining to particle heterogeneity, temporal factors, exposure characterization, disease endpoints, and identification of the study population. Conclusion: Consideration of these issues provides the foundation for initiating epidemiologic research, on workers exposed, to engineered nanoparticles.
Biological-effects; Biological-factors; Biological-monitoring; Exposure-levels; Health-hazards; Immune-system; Immune-reaction; Immunology; Work-areas; Workplace-studies; Particle-aerodynamics; Epidemiology; Nanotechnology
Paul A. Schulte, NIOSH, Cender for Disease Control & Prevention, Edicucation and Information Division, 4676 Columbia Parkway, MS C-14, Cincinnati, OH 45226
Journal of Occupational and Environmental Medicine