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Antioxidant activity of tetrandrine and its inhibition of quartz-induced lipid-peroxidation.

Authors
Shi-XI; Mao-Y; Saffiotti-U; Wang-LY; Rojanasakul-Y; Leonard-SS; Vallyathan-V
Source
J Toxicol Environ Health 1995 Oct; 46(2):233-248
NIOSHTIC No.
20035135
Abstract
Tetrandrine is a benzylisoquinoline alkaloid that has been used in China as an antifibrotic drug to treat the lesions of silicosis. Its mechanism in the treatment of silicosis is unclear. Electron spin resonance (ESR) spin trapping was employed to investigate the antioxidant properties of tetrandrine. The spin trap used was 5,5-dimethyl-1-pyrroline N-oxide (DMPO). Tetrandrine efficiently reacted with hydroxyl ((OH)-O-.) radicals with a reaction rate of approximately 1.4 x 10(10) M(-1) s(-1). The (OH)-O-. radicals were generated by the Fenton reaction [Fe(II) + H2O2) as well as by reaction of chromium(V) with H2O2. Similar results were obtained using (OH)-O-. radicals generated by reaction of freshly fractured quartz particles with aqueous medium. Tetrandrine also scavenged superoxide (O-2(-)) radicals produced from xanthine/xanthine oxidase. The effect or tetrandrine on lipid peroxidation induced by freshly fractured quartz particles was evaluated using linoleic acid as a model lipid. The results showed that tetrandrine caused a significant inhibition on freshly fractured quartz-induced lipid peroxidation.
Keywords
Dust-exposure; Fibrogenesis; Histopathology; Inhalation-studies; Lipid-peroxidation; Peroxidases; Pulmonary-disorders; Quartz-dust; Risk-analysis; Silica-dusts; Silicates
Contact
XI Shi, NCI, Experimental Pathology Laboratory, Bldg 41, Room C301, Bethesda, MD 20892
CODEN
JTEHD6
Publication Date
19951001
Document Type
Journal Article
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0098-4108
NIOSH Division
HELD
Source Name
Journal of Toxicology and Environmental Health
State
MD; WV
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