Inflammation - more than one explanation - response.
Vallyathan-V; Castranova-V; Weber-K
Environ Health Perspect 1995 Nov; 103(11):985
We appreciate the interest shown by Dr. Ginsburg in our recent conference proceedings (EHP 102, supplement 10). As stated in the preface of those proceedings, The Oxygen Radicals and Lung Injury Conference was the first of its kind dedicated to pulmonary science. Therefore, in this conference, the primary attempt was to focus on oxygen radicals and their involvement in toxic insults and the ensuing pathophysiological processes in the lung. We did not ignore the importance of multifactorial relationships of other cellular reactions and products involved in cellular damage and injury. In fact, these issues were addressed in the presentations of Ward (1), Holian et al. (2), Repine (3), Torphy et al. (4), and Demers and Kuhn (5). The complex network of micromolecular reactions have not been fully defined to understand the coordination, modulation, and integration of cellular functions. In many pulmonary diseases (e.g., cancer, emphysema, pneumoconiosis) in which oxygen radicals are implicated, the disease becomes evident only after several years. Subtle damage or changes to biomolecules and their relationships to the coordination and interactions of oxygen radical generation and degradation are important issues to be dealt with in greater detail to understand the synergistic concepts of lung dieases. We hope that future conferences will address these and other issues.
Biological-effects; Biological-transport; Cell-function; Cellular-function; Cellular-transport-mechanism; Lung; Lung-disease; Lung-disorders; Lung-irritants; Molecular-biology; Oxidation; Oxidative-metabolism; Physiological-disorders; Physiological-effects; Physiological-response; Physiological-testing; Physiology; Physiopathology; Pulmonary-disorders; Pulmonary-system; Pulmonary-system-disorders
Val Vallythan, CDC, Health Effects Laboratory Division, National Institute for Occupational Safety and Health, 1095 Willowdale Rd., Morgantown, WV 26505
Environmental Health Perspectives