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Manganese accumulation in the mouse ear following systemic exposure.

Authors
Ma-C; Schneider-SN; Miller-M; Nebert-DW; Lind-C; Roda-SM; Afton-SE; Caruso-JA; Genter-MB
Source
J Biochem Mol Toxicol 2008 Sep; 22(5):305-310
NIOSHTIC No.
20035117
Abstract
There is evidence in human populations that exposure to manganese (Mn), or Mn in combination with excessive noise exposure, results in hearing loss. Quantitative reverse-transcriptase polymerase chain reaction revealed expression of the metal transporters DMT1, ZIP8, and ZIP14 in control mouse ears. ZIP8 is known to have a high affinity (K(m) = 2.2 microM) for Mn transport, and ZIP8 protein was localized to the blood vessels of the ear by immunohistochemistry. We treated mice (strains C57BL/6J and DBA/2J) with Mn (100 mg/kg MnCl(2), by subcutaneous injection, on three alternating days), and Mn was significantly elevated in the ears of the treated mice. Mn concentrations remained elevated over controls for at least 2 weeks after treatment. These studies demonstrate that metal transporters are present in the mouse ear and that Mn can accumulate in the ear following systemic exposure. Future studies should focus on whether Mn exposure is associated with hearing deficits.
Keywords
Biochemical-indicators; Biochemistry; Biohazards; Biological-effects; Biological-factors; Biological-systems; Chemical-hypersensitivity; Ear-disorders; Ears; Exposure-assessment; Exposure-methods; Health-hazards; Hearing-disorders; Hearing-impairment; Hearing; Hearing-acuity; Immune-system; Immunochemistry; Laboratory-animals; Laboratory-testing; Microchemistry; Molecular-biology; Occupational-exposure; Occupational-hazards; Statistical-analysis; Safety-measures; Author Keywords: Manganese; Mouse; Ear; ZIP8; Slc39a8; Slc39a14; Dmt1
Contact
Mary Beth Genter, Department of Environmental Health, University of Cincinnati, Cincinnati, OH 45267-0056
CODEN
JBMTFQ
CAS No.
7439-96-5
Publication Date
20080901
Document Type
Journal Article
Email Address
Marybeth.genter@uc.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T42-OH-008432
Issue of Publication
5
ISSN
1095-6670
Source Name
Journal of Biochemical and Molecular Toxicology
State
OH
Performing Organization
University of Cincinnati
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