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Manganese exposure among smelting workers: blood manganese-iron ratio as a novel tool for manganese exposure assessment.

Authors
Cowan-DM; Fan-Q; Zou-Y; Shi-X; Chen-J; Aschner-M; Rosenthal-FS; Zheng-W
Source
Biomarkers 2009 Feb; 14(1):3-16
NIOSHTIC No.
20035103
Abstract
Unexposed control subjects (n = 106), power distributing and office workers (n = 122), and manganese (Mn)-exposed ferroalloy smelter workers (n = 95) were recruited to the control, low and high groups, respectively. Mn concentrations in saliva, plasma, erythrocytes, urine and hair were significantly higher in both exposure groups than in the controls. The Fe concentration in plasma and erythrocytes, however, was significantly lower in Mn-exposed workers than in controls. The airborne Mn levels were significantly associated with Mn/Fe ratio (MIR) of erythrocytes (eMIR) (r = 0.77, p < 0.01) and plasma (pMIR) (r = 0.70, p < 0.01). The results suggest that the MIR may serve as a useful biomarker to distinguish Mn-exposed workers from the unexposed, control population.
Keywords
Biological-effects; Biological-factors; Biomarkers; Environmental-health; Iron-oxide-fumes; Metabolism; Manganese-compounds; Occupational-health; Occupational-hazards; Occupational-exposure; Occupational-respiratory-disease; Pulmonary-system-disorders; Quantitative-analysis; Risk-factors; Statistical-analysis; Toxicology; Toxins; Toxic-effects; Author Keywords: Manganese; iron; exposure assessment; Mn-Fe ratio; biomarker; saliva; erythrocyte; smelter
Contact
Wei Zheng, Professor of Health Sciences and Toxicology, Purdue University School of Health Sciences, 550 Stadium Mall Drive, CIVL-1163D, West Lafayette, Indiana 47907
CODEN
BIOMFA
CAS No.
7439-96-5; 7439-89-6
Publication Date
20090201
Document Type
Journal Article
Email Address
wzheng@purdue.edu
Funding Type
Grant
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-T01-OH-008615
Issue of Publication
1
ISSN
1354-750X
Source Name
Biomarkers
State
IN; TN
Performing Organization
Purdue University, West Lafayette, Indiana
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