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Silicosis in the lymph nodes: the canary in miner?

Authors
Cox-Ganser-JM; Burchfiel-CM; Fekedulegn-D; Andrew-ME; Ducatman-BS
Source
J Occup Environ Med 2009 Feb; 51(2):164-169
NIOSHTIC No.
20035071
Abstract
Objectives: to investigate evidence that lymph node silicosis can precede parenchymal silicosis. Methods: the study population was comprised of 264 deceased male uranium miners for whom two or more of four pathologists agreed on the presence or absence of silicosis in lymph nodes and lung parenchyma. We had work histories and silica exposure estimates. Results: twenty percent of the miners had lymph node silicosis only, 4% had parenchymal silicosis only, and 39% had both. Silica exposure was lower for miners with lymph node silicosis only than for those with both lymph node and parenchymal silicosis. Lymph node silicosis was associated with parenchymal silicosis after adjustment for silica exposure. Conclusions: our results are consistent with silicosis potentially occurring in lymph nodes before the parenchyma. Lymph node damage could impair silica clearance and increase the risk for parenchymal silicosis.
Keywords
Epidemiology; Lymph-nodes; Lymphatic-system; Miners; Mining-industry; Pulmonary-system-disorders; Respiratory-system-disorders; Statistical-analysis; Silica-dusts; Silicate-miners; Uranium-mining; Work-environment
Contact
Jean Cox-Ganser, PhD, CDC, NIOSH, Division of Respiratory Disease Studies, 1095 Willowdale Road, Suite H-2800, Morgantown, WV 26508
CODEN
JOEMFM
CAS No.
7440-21-3
Publication Date
20090201
Document Type
Journal Article
Email Address
jjc8@cdc.gov
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
1076-2752
NIOSH Division
DRDS; HELD
Source Name
Journal of Occupational and Environmental Medicine
State
WV
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