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Human papillomavirus-16 modifies the association between fruit consumption and head and neck squamous cell carcinoma.

Authors
Meyer-MS; Applebaum-KM; Furniss-CS; Peters-ES; Luckett-BG; Smith-JF; Bryan-J; McClean-MD; Marsit-C; Kelsey-KT
Source
Cancer Epidemiol Biomark Prev 2008 Dec; 17(12):3419-3426
NIOSHTIC No.
20034960
Abstract
Human papillomavirus-16 (HPV-16) is a risk factor for head and neck squamous cell carcinoma (HNSCC). HPV-positive cancers have distinct disease cofactors and improved survival following treatment. There is conflicting evidence of a protective association of fruit consumption with HNSCC. As HPV-related disease is clinically distinct, we investigated whether the association between fruit consumption and HNSCC risk was modified by exposure to HPV-16. We studied 270 cases and 493 controls with fruit intake information and known HPV-16 antibody status. Cases were identified at nine Boston-area medical facilities between 1999 and 2003. Controls were randomly selected from the greater population and frequency matched to cases by age, gender, and town of residence. Controlling for age, gender, race, smoking, alcohol, total energy intake, body mass index, and education, the seronegative individuals had a significantly lower risk of HNSCC with increasing total fruit consumption [odds ratio (OR)(tertile 2), 0.60; 95% confidence interval (95% CI), 0.38-0.95; OR(tertile 3), 0.57; 95% CI, 0.35-0.95] and specifically increasing citrus fruit consumption (OR(tertile 2), 0.61; 95% CI, 0.39-0.97; OR(tertile 3), 0.59; 95% CI, 0.37-0.96). However, among the seropositive, risk increased with greater fruit consumption (OR(tertile 2), 2.27; 95% CI, 0.92-5.58; OR(tertile 3), 1.40; 95% CI, 0.55-3.59) and citrus fruit consumption (OR(tertile 2), 3.35; 95% CI, 1.36, 8.24; OR(tertile 3), 3.15; 95% CI, 1.23-8.08). This interaction was statistically significant (P < 0.05), showing that fruit consumption was associated with a reduced HNSCC risk among HPV-16-seronegative individuals but an increased HNSCC risk among the HPV-16-seropositive individuals. These findings suggest that dietary factors dramatically alter the pattern of occurrence of HPV-associated HNSCC and show that viral-related disease is clinically and etiologically distinct.
Keywords
Cancer-rates; Disease-incidence; Disease-prevention; Disease-vectors; Racial-factors; Substance-abuse; Weight-factors; Age-factors; Statistical-analysis; Education; Exposure-methods; Clinical-diagnosis; Viral-diseases
Contact
Karl T. Kelsey, Departments of Community Health and Pathology and Laboratory Medicine, Center for Environmental Health and Technology, Brown University, Providence, RI 02912
CODEN
CEBPE4
Publication Date
20081201
Document Type
Journal Article
Email Address
Karl_Kelsey@brown.edu
Funding Type
Grant
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-009390
Issue of Publication
2
ISSN
1055-9965
Priority Area
Manufacturing
Source Name
Cancer Epidemiology, Biomarkers & Prevention
State
MA; LA; CO; RI; PA
Performing Organization
Boston University Medical Campus
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