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Adaptive stretch-shortening contractions: diminished regenerative capacity with aging.

Authors
Baker-BA; Hollander-MS; Mercer-RR; Kashon-ML; Cutlip-RG
Source
Appl Physiol Nutr Metab 2008 Dec; 33(6):1181-1191
NIOSHTIC No.
20034922
Abstract
This study determined the age-related changes in acute events responsible for initiating skeletal muscle remodeling and (or) regeneration in the tibialis anterior muscle following a bout of stretch-shortening contractions (SSCs). Changes in muscle performance and morphology were quantified in young and old rats, following an acute exposure to adaptive SSCs at 6, 24, 48, 72, and 120 h postexposure (n = 6 for each age at each recovery period). Following SSC exposure, all performance measures were decreased in old rats throughout the 120 h acute phase. Estimates of edema were increased in the old vs. young exposed muscle at 120 h recovery. Both young and old rats displayed an increase in developmental myosin heavy chain (MHCdev+) labeling in the exposed muscle, indicating muscle regeneration. However, old rats displayed diminished MHCdev+ labeling, compared with young rats, suggesting limited remodeling and (or) regenerative capacity. Based on these data, diminished local muscle remodeling and (or) regeneration with aging may limit skeletal muscle adaptation following mechanical loading.
Keywords
Exposure-assessment; Biological-effects; Exposure-methods; Statistical-analysis; Laboratory-animals; Musculoskeletal-system; Age-factors; Muscle-contraction; Muscle-physiology; Muscle-stress; Muscle-tension; Muscles; Physiological-effects; Physiological-factors; Physiological-measurements; Physiological-response; Physiological-testing; Author Keywords: Aging; Muscle regeneration; Inflammation; Myosin heavy chain; Stretch-shortening contractions
Publication Date
20081101
Document Type
Journal Article
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
1715-5320
NIOSH Division
HELD
Source Name
Applied Physiology, Nutrition, and Metabolism
State
WV
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