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Development of historical exposure estimates for an epidemiologic study of beryllium sensitization and chronic beryllium disease at a beryllium production facility.

Authors
Virji-MA; Schuler-CR; Stanton-MI; Day-GA; Stefaniak-AB; Kent-MS; Kreiss-K
Source
Epidemiology 2008 Nov; 19(6)(S):S105
NIOSHTIC No.
20034919
Abstract
Background: a number of epidemiologic studies have reported elevated prevalence of beryllium sensitization and chronic beryllium disease among employees in specific work processes. However, exposure-response relationships have been inconsistent, perhaps due to exposure misclassification from a lack of accurate, precise and/or biologically relevant estimates of historical exposures. In 1999, an epidemiologic study surveyed 264 workers hired after 1/1/1994 at a beryllium production facility. Methods: personal (full-shift) beryllium exposure data from a 1999 exposure survey (n = 3,906) were used to obtain mean baseline exposure estimates (BEE) for 272 jobs in a job-exposure matrix (JEM). We used historical general-area air samples (n = 77,183) collected between 1994 and 1999 to estimate the fractional annual change in exposure for 29 different work-process areas. The data were modeled using tobit regression to account for the left censoring of the air samples (17%-98%
Keywords
Work-environment; Exposure-assessment; Exposure-methods; Occupational-exposure; Epidemiology; Biohazards; Biological-effects; Biological-factors; Biological-monitoring; Biological-systems; Chemical-hypersensitivity; Exposure-assessment; Exposure-levels; Exposure-methods; Statistical-analysis; Workplace-studies; Work-environment; Work-areas; Chemical-hypersensitivity
CODEN
EPIDEY
CAS No.
7440-41-7
Publication Date
20081101
Document Type
Abstract
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
1044-3983
NIOSH Division
DRDS
Priority Area
Manufacturing
Source Name
Epidemiology; ISEE 20th Annual Conference, Pasadena, California, October 12-16, 2008
State
WV
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