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Prevalence in the United States of selected candidate gene variants. Third National Health and Nutrition Examination Survey, 1991-1994.

Authors
Chang-MH; Lindegren-ML; Butler-MA; Chanock-SJ; Dowling-NF; Gallagher-M; Moonesinghe-R; Moore-CA; Ned-RM; Reichler-MR; Sanders-CL; Welch-R; Yesupriya-A; Khoury-MJ
Source
Am J Epidemiol 2009 Jan; 169(1):54-66
NIOSHTIC No.
20034907
Abstract
Population-based allele frequencies and genotype prevalence are important for measuring the contribution of genetic variation to human disease susceptibility, progression, and outcomes. Population-based prevalence estimates also provide the basis for epidemiologic studies of gene-disease associations, for estimating population attributable risk, and for informing health policy and clinical and public health practice. However, such prevalence estimates for genotypes important to public health remain undetermined for the major racial and ethnic groups in the US population. DNA was collected from 7,159 participants aged 12 years or older in Phase 2 (1991-1994) of the Third National Health and Nutrition Examination Survey (NHANES III). Certain age and minority groups were oversampled in this weighted, population-based US survey. Estimates of allele frequency and genotype prevalence for 90 variants in 50 genes chosen for their potential public health significance were calculated by age, sex, and race/ethnicity among non-Hispanic whites, non-Hispanic blacks, and Mexican Americans. These nationally representative data on allele frequency and genotype prevalence provide a valuable resource for future epidemiologic studies in public health in the United States.
Keywords
Risk-factors; Models; Mathematical-models; Statistical-analysis; Author Keywords: Alleles; Continental population groups; Ethnic groups; Genetics; population; Genotype; Nutrition surveys; Polymorphism; genetic; Prevalence
Contact
Man-huei Chang, National Office of Public Health Genomics, Centers for Disease Control and Prevention, 4770 Buford Highway, Mail Stop K89, Atlanta, GA 30341
CODEN
AJEPAS
Publication Date
20090101
Document Type
Journal Article
Email Address
mdc9@cdc.gov
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0002-9262
NIOSH Division
DART
Priority Area
Manufacturing
Source Name
American Journal of Epidemiology
State
GA; MD
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