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Induction of CYP4F3 in white blood cells from benzene-poisoning patients and human HL60 cells.

Authors
Zhao-Z; Mao-Z; Bi-Y; Xia-Y; Tao-N; Li-L; He-X; Ma-Q
Source
17th International Symposium on Microsomes and Drug Oxidations, Saratoga Springs, New York, USA, July 6-10, 2008. Kaminsky LS, ed., Bologna, Italy: Medimond S.r.l., 2008 Jul; :103-107
Link
NIOSHTIC No.
20034765
Abstract
Exposure to benzene elicits a range of hematotoxicity from leukopenia to leukemia. We used microarray to analyze differential gene expression in the white blood cells (WBC) from 7 patients diagnosed with occupational benzene poisoning compared with 7 matched controls. All patients exhibited elevated expression of CYP4F3, a leukotriene B4 (LTB4) omega-hydroxylase critical in the inactivation of LTB4 in polymorphonuclear leukocytes (PMN), with the fold of induction between 3 and 71. CYP4F3 was also induced in cultured promyolocytic leukemia cells (HL-60) by a benzene metabolite, phenol, similarly to all-trans retinoic acid (ATRA). Induction of CYP4F3 may playa role in benzene hematotoxicity and serve as a biomarker of benzene exposure and toxicity.
Keywords
Benzenes; Benzene-poisoning; Hematopoietic-system; Blood-disorders; Biomarkers; Solvents
CAS No.
71-43-2
Publication Date
20080706
Document Type
Conference/Symposia Proceedings
Editors
Kaminsky LS
Fiscal Year
2008
NTIS Accession No.
NTIS Price
NIOSH Division
HELD
Source Name
17th International Symposium on Microsomes and Drug Oxidations, Saratoga Springs, New York, USA, July 6-10, 2008
State
WV
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