Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Pesticide/environmental exposures and Parkinson's disease in East Texas.

Dhillon-AS; Tarbutton-GL; Levin-JL; Plotkin-GM; Lowry-LK; Nalbone-JT; Shepherd-S
J Agromed 2008 Jun; 13(1):37-48
Epidemiological evidence suggests that pesticides and other environmental exposures may have a role in the etiology of idiopathic Parkinson's disease (PD). However, there is little human data on risk associated with specific pesticide products, including organic pesticides such as rotenone with PD. Using a case-control design, this study examined self-reports of exposure to pesticide products, organic pesticides such as rotenone, and other occupational and environmental exposures on the risk of PD in an East Texas population. The findings demonstrated significantly increased risk of PD with use of organic pesticides such as rotenone in the past year in gardening (OR = 10.9; 95% CI = 2.5-48.0) and any rotenone use in the past (OR = 10.0; 95% CI = 2.9-34.3). Use of chlorpyrifos products (OR = 2.0; 95% CI = 1.02-3.8), past work in an electronics plant (OR = 5.1; 95% CI = 1.1-23.6), and exposure to fluorides (OR = 3.3; 95% CI = 1.03-10.3) were also associated with significantly increased risk. A trend of increased PD risk was observed with work history in paper/lumber mill (OR = 6.35; 95% CI = 0.7-51.8), exposure to cadmium (OR = 5.3; 95% CI = 0.6-44.9), exposure to paraquat (OR = 3.5; 95% CI = 0.4-31.6), and insecticide applications to farm animals/animal areas and agricultural processes (OR = 4.4; 95% CI = 0.5-38.1). Cigarette smoking, alcohol use, and fish intake were associated with reduced risk. In summary, this study demonstrates an increased risk of PD associated with organic pesticides such as rotenone and certain other pesticides and environmental exposures in this population.
Farmers; Agriculture; Agricultural-industry; Agricultural-workers; Occupational-hazards; Occupational-health; Occupational-exposure; Breathing; Pulmonary-function; Pulmonary-system; Respiration; Statistical-analysis; Pesticides-and-agricultural-chemicals; Insecticides; Risk-analysis; Risk-factors; Environmental-contamination; Environmental-exposure; Environmental-hazards; Environmental-health-monitoring; Epidemiology; Toxic-effects
Department of Occupational Health Sciences, University of Texas Health Science Center at Tyler, Tyler, Texas 75708
Publication Date
Document Type
Journal Article
Email Address
Funding Type
Cooperative Agreement
Fiscal Year
NTIS Accession No.
NTIS Price
Identifying No.
Issue of Publication
Source Name
Journal of Agromedicine
Performing Organization
University of Texas Health Center at Tyler