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Routine diagnostic x-ray examinations and increased frequency of chromosome translocations among US radiologic technologists.

Authors
Sigurdson-AJ; Bhatti-P; Preston-DL; Doody-MM; Karnpa-D; Alexander-BH; Petibone-D; Yong-LC; Edwards-AA; Ron-E; Tucker-JD
Source
Cancer Res 2008 Nov; 68(21):8825-8831
NIOSHTIC No.
20034728
Abstract
The U.S. population has nearly one radiographic examination per person per year, and concern about cancer risks associated with medical radiation has increased. Radiologic technologists were surveyed to determine whether their personal cumulative exposure to diagnostic X-rays was associated with increased frequencies of chromosome translocations, an established radiation biomarker and possible intermediary suggesting increased cancer risk. Within a large cohort of U.S. radiologic technologists, 150 provided a blood sample for whole chromosome painting and,were interviewed about past X-ray examinations. The number and types of examinations reported were converted to a red bone marrow (RBM) dose score with units that approximated 1 mGy. The relationship between dose score and chromosome translocation frequency was assessed using Poisson regression. The estimated mean cumulative RBM radiation dose score was 49 (range, 0-303). After adjustment for age, translocation frequencies significantly increased with increasing RBM dose score with an estimate of 0.004 translocations per 100 cell equivalents per score unit (95% confidence interval, 0.002-0.007; P < 0.001). Removing extreme values or adjustment for gender, cigarette smoking, occupational radiation dose, allowing practice X-rays while training, work with radioisotopes, and radiotherapy for benign conditions did not affect the estimate. Cumulative radiation exposure from routine X-ray examinations was associated independently with increased chromosome damage, suggesting the possibility of elevated long-term health risks, including cancer. The slope estimate was consistent with expectation based on cytogenetic experience and atomic bomb survivor data.
Keywords
Genes; Genetic-factors; Cancer-rates; Cell-biology; Cell-cultures; Cell-growth; Cell-morphology; Chromosome-disorders; Radiation; Radiation-exposure; Radiation-hazards; Radiation-measurement; Radiation-sources; Statistical-analysis; Biological-monitoring; Risk-analysis; Risk-factors; Cell-biology; Cell-growth; Cell-transformation; Cellular-structures; Age-factors; Age-groups; Genetic-factors; Smoking
Contact
Alice J. Sigurdson, Radiation Epidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, NIH, Department of Health and Human Services, 6120 Executive Boulevard, EPS 7060, MSC 7238, Bethesda, MD 20892
CODEN
CNREA8
Publication Date
20081101
Document Type
Journal Article
Email Address
sigurdsa@mail.nih.gov
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
21
ISSN
0008-5472
NIOSH Division
DSHEFS
Priority Area
Manufacturing
Source Name
Cancer Research
State
WV
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