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Aging-dependent regulation of antioxidant enzymes and redox status inchronically loaded rat dorsiflexor muscles.

Authors
Ryan-MJ; Dudash-HJ; Docherty-M; Geronilla-KB; Baker-BA; Haff-GG; Cutlip-RG; Alway-SE
Source
J Geront, Ser A Biol Sci Med Sci 2008 Oct; 63A(10):1015-1026
NIOSHTIC No.
20034724
Abstract
This study compares changes in the pro-oxidant production and buffering capacity in young and aged skeletal muscle after exposure to chronic repetitive loading (RL). The dorsiflexors from one limb of young and aged rats were loaded 3 times/week for 4.5 weeks using 80 maximal stretch-shortening contractions per session. RL increased H2O2 in tibialis anterior muscles of young and aged rats and decreased the ratio of reduced/oxidized glutathione and lipid peroxidation in aged but not young adult animals. Glutathione peroxidase (GPx) activity decreased whereas catalase activity increased with RL in muscles from young and aged rats. RL increased CuZn superoxide disumutase (SOD) and Mn SOD protein concentration and CuZn SOD activity in muscles from young but not aged animals. There were no changes in protein content for GPx-1 and catalase or messenger RNA for any of the enzymes studied. These data show that aging reduces the adaptive capacity of muscles to buffer increased pro-oxidants imposed by chronic RL.
Keywords
Laboratory-animals; Animals; Animal-studies; Musculoskeletal-system; Muscle-stress; Muscle-physiology; Age-factors
Contact
Stephen E. Always, Laboratory of Muscle Biology and Sarcopenia, Division of Exercise Physiology, West Virginia University School of Medicine, Morgantown, WV 26506
CODEN
JOGEA3
Publication Date
20081001
Document Type
Journal Article
Email Address
salway@hsc.wvu.edu
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
10
ISSN
0022-1422
NIOSH Division
HELD
Source Name
The Journals of Gerontology Series A: Biological Sciences and Medical Sciences
State
WV
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