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Cancer incidence among pesticide applicators exposed to captan in the Agricultural Health Study.

Authors
Greenburg-DL; Rusiecki-J; Koutros-S; Dosemeci-M; Patel-R; Hines-CJ; Hoppin-JA; Alavanja-MCR
Source
Cancer Causes Control 2008 Dec; 19(10):1401-1407
NIOSHTIC No.
20034709
Abstract
Objective: Captan is a widely used antifungal pesticide whose potential to cause cancer in humans is uncertain. Methods: we evaluated the incidence of cancer among pesticide applicators exposed to captan in the Agricultural Health Study. Detailed information on pesticide exposure and lifestyle factors was obtained from self-administered enrollment questionnaires completed between 1993 and 1997. Results: of the 48,986 applicators enrolled 4,383 (9%) had applied captan. Median follow-up time was 9.14 years. Poisson regression analysis was used to estimate relative risks (RR) for cancer subtypes by tertiles of captan exposure. We investigated risk for all cancers combined and sites of cancer for which at least 15 cases occurred among captan-exposed applicators. These sites included cancers of the prostate, lung, and colon, blood-related cancers, and colorectal cancers. During follow-up 2,912 incident primary cases of cancer were identified. No association between the highest tertile of captan exposure (>67.375 intensity-weighted days) and development of all cancers (RR = 0.89; 95% CI, 0.71-1.13) or cancer of any specific site was observed. Conclusion: although our study is limited by low numbers of observed cancer cases and follow-up time of 9.14 years, it does not provide evidence of an increased risk for the development of cancer at the investigated sites.
Keywords
Agricultural-chemicals; Agricultural-workers; Cancer-rates; Chemical-hypersensitivity; Chemical-properties; Statistical-analysis; Questionnaires; Quantitative-analysis; Pesticides; Pesticides-and-agricultural-chemicals; Risk-analysis
Contact
Jennifer Rusiecki, Department of Medicine-EDP, Uniformed Services University of the Health Sciences, 4301 Jones Bridge Rd., Bethesda, MD 20814
CODEN
CCCNEN
CAS No.
133-06-2
Publication Date
20081201
Document Type
Journal Article; Academic/Scholarly
Email Address
jrusiecki@usuhs.mil
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Issue of Publication
10
ISSN
0957-5243
NIOSH Division
DSHEFS
Priority Area
Agriculture, Forestry and Fishing
Source Name
Cancer Causes and Control
State
OH
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