Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Fiber deposition in the tracheobronchial region: deposition equations.

Authors
Zhou-Y; Su-WC; Cheng-YS
Source
Inhal Toxicol 2008 Oct; 20(13):1191-1198
NIOSHTIC No.
20034685
Abstract
A lung deposition model for fibrous aerosol needs accurate deposition equations for different regions of the human respiratory tract. For fiber deposition in the tracheobronchial region there are several theoretical and empirical equations to predict deposition efficiency in the impaction-dominant region. However, few were verified with experimental data. We have obtained experimental data of fiber deposition in realistic human airway replicas using carbon fibers. Comparison of experimental data and existing deposition models yield variable results, with some models performing better than other models. There was no consistent agreement found over the Stokes number range of experimental data. A generic empirical model for fiber deposition in the tracheobronchial region was developed based on all carbon fiber deposition data in human lung replicas. This model includes the size of fibers and the geometry of the tracheobronchial bifurcation. Because it is difficult to develop only one equation for all data from the trachea to the major bronchial bifurcations, the deposition patterns in the trachea and first generation were each predicted by their own equations. An additional equation was developed for the second to fourth generations. This model, combined with oral and nasal deposition predictions which will be published elsewhere, can be used to investigate the inhalation dosimetry and deposition patterns of fibers in human lungs for assessing occupational hazards and air pollutants.
Keywords
Aerosols; Aerosol-particles; Respiratory-system-disorders; Fibrous-dusts; Particle-aerodynamics; Particle-counters; Particulate-sampling-methods; Particulate-dust; Respiratory-irritants; Air-contamination; Air-monitoring; Air-quality; Air-sampling; Air-sampling-techniques; Asbestos-fibers; Models; Statistical-analysis; Respiratory-function-tests; Qualitative-analysis; Mathematical-models; Laboratory-testing; Laboratory-techniques
Contact
Yue Zhou, 2425 Ridgecrest Dr. SE, Albuquerque, NM 87108
CODEN
INHTE5
Publication Date
20081001
Document Type
Journal Article
Email Address
yzhou@lrri.org
Funding Type
Grant
Fiscal Year
2009
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003900
Issue of Publication
13
ISSN
0895-8378
Source Name
Inhalation Toxicology
State
NM
Performing Organization
Lovelace Biomedical & Environmental Research
TOP