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Mother's menopausal age is associated with her daughter's early follicular phase urinary follicle-stimulating hormone level.

Authors
Steiner-AZ; Baird-DD; Kesner-JS
Source
Menopause 2008 Sep; 15(5):940-944
NIOSHTIC No.
20034626
Abstract
Objective: Early follicular phase follicle-stimulating hormone (FSH), a marker of ovarian reserve, has been used to predict time to menopause. A mother's age at menopause is related to her daughter's age at menopause, possibly because of genetic factors. In this study we sought to determine the relationship between maternal age at menopause and early follicular phase FSH of premenopausal daughters. Design: The Uterine Fibroid Study enrolled women randomly selected from a prepaid health plan, collected questionnaire data, and obtained earl), follicular phase urine samples for a Subset of participants. For this secondary analysis, premenopausal women between the ages of 35 and 46 years, who provided a urine sample on cycle day 2, 3, 4, or 5 and their mother's age at natural menopause (n = 182) were selected from the original cohort. Initially bivariate analysis and subsequently regression modeling were performed to assess the independent relationship between maternal age at menopause and urinary creatinine-corrected FSH. Results: Unadjusted analyses and those adjusting for age (mean +/- SD, 405 +/- 3.2 y), smoking status (16% current smokers), and body mass index (26.8 +/- 6.9 kg/m(2)) showed a significant association between maternal age at menopause and daughter's urinary FSH level (P < 0.04). Women whose mothers experienced earlier menopause had higher urinary FSH levels. Conclusions: The significantly increased FSH values among women whose mothers experienced early menopause is consistent with previously reported associations between mother's and daughter's age of menopause. FSH, a marker of ovarian reserve, is influenced by both genetic and environmental factors. Future epidemiologic studies on FSH should include collection of information on maternal age at menopause.
Keywords
Epidemiology; Age-factors; Genetic-factors; Genetics; Urogenital-system; Statistical-analysis; Environmental-exposure; Environmental-factors
Contact
Anne Z. Steiner, MD, Department of Obstetrics and Gynecology, University of North Carolina School of Medicine, Chapel Hill, NC 27515
CODEN
MENOF2
Publication Date
20080901
Document Type
Journal Article
Email Address
asteiner@med.unc.edu
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
1072-3714
NIOSH Division
DART
Priority Area
Agriculture, Forestry and Fishing; Mining
Source Name
Menopause: Journal of the North American Menopause Society
State
OH
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