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A meta-analysis of studies investigating the effects of lead exposure on nerve conduction.

Authors
Krieg-EF; Chrislip-DW; Brightwell-WS
Source
Arch Toxicol 2008 Aug; 82(8):531-542
NIOSHTIC No.
20034428
Abstract
Group means from nerve conduction studies of persons exposed to lead were used in a meta-analysis. Differences between the control and exposed groups, and the slopes between nerve conduction measurements and log(10) blood lead concentrations were estimated using mixed models. Conduction velocity was reduced in the median, ulnar, and radial nerves in the arm, and in the deep peroneal nerve in the leg. Distal latencies of the median, ulnar, and deep peroneal nerves were longer. No changes in the amplitudes of compound muscle or nerve action potentials were detected. The lowest concentration at which a relationship with blood lead could be detected was 33.0 mu g/dl for the nerve conduction velocity of the median sensory nerve. Lead may reduce nerve conduction velocity by acting directly on peripheral nerves or by acting indirectly, for example, on the kidney or liver.
Keywords
Models; Physiology; Physiological-testing; Physiological-factors; Exposure-assessment; Chemical-properties; Toxic-effects; Statistical-analysis; Cellular-function; Cellular-reactions; Nerve-function; Nerve-tissue; Nervous-system; Nervous-system-function; Lead-compounds; Nephrological-disorders; Nephrotoxicity; Liver-cells; Liver-function; Hepatotoxicity; Bloodborne-pathogens; Biological-effects; Biological-factors
Contact
Edward F. Krieg Jr, Robert A. Taft Laboratories, National Institute for Occupational Safety and Health, 4676 Columbia Parkway, MS C-22, Cincinnati, OH 45226
CODEN
ARTODN
Publication Date
20080801
Document Type
Journal Article
Email Address
erk3@cdc.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
8
ISSN
0340-5761
NIOSH Division
DART
Source Name
Archives of Toxicology
State
OH
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