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Effects of exposure to polychlorinated biphenyls and organochlorine pesticides on thyroid function during pregnancy.

Authors
Chevrier-J; Eskenazi-B; Holland-N; Bradman-A; Barr-DB
Source
Am J Epidemiol 2008 Aug; 168(3):298-310
NIOSHTIC No.
20034381
Abstract
In this study, the authors' objective was to determine whether serum concentrations of polychlorinated biphenyls (PCBs), hexachlorobenzene, p,p'-dichlorodiphenyl trichloroethane (DDT), o,p'-DDT, and p,p'-dichlorodiphenyl dichloroethylene (DDE) are associated with thyroid function during pregnancy. These compounds, as well as thyroid-stimulating hormone, total thyroxine, and free thyroxine, were measured in serum samples collected between October 1999 and October 2000 from 334 pregnant women living in the Salinas Valley, California. Data were analyzed by multivariate linear regression. After adjustment for covariates, seven of the 19 PCB congeners detected in more than 75% of participants and the sum of those congeners were negatively associated with free thyroxine concentrations. PCBs 44, 52, and 183 remained significant after the exclusion of two outliers. Hexachlorobenzene concentrations were negatively associated with both free thyroxine and total thyroxine. PCB and hexachlorobenzene concentrations were strongly correlated, which hampered the authors' ability to identify their independent associations with thyroid function. None of the exposures under study were associated with thyroid-stimulating hormone. Results suggest that exposure to PCBs and/or hexachlorobenzene at background levels may affect thyroid function during pregnancy. These findings are of particular significance, since thyroid hormones of maternal origin may play an essential role in fetal neurodevelopment.
Keywords
Pregnancy; Children; Prenatal-exposure; Risk-factors; Risk-analysis; Exposure-levels; Exposure-assessment; Biological-monitoring; Health-hazards; Health-surveys; Neurotoxic-effects; Neurotoxins; Statistical-analysis; Chelating-agents; Chemical-composition; Chemical-hypersensitivity; Chemical-properties; Hormone-activity; Hormones
Contact
Dr. Brenda Eskenazi, Center for Children's Environmental Health Research, School of Public Health, University of California, Berkeley, 2150 Shattuck Avenue, Suite 600, Berkeley, CA 94704-7380
CODEN
AJEPAS
CAS No.
11097-69-1; 118-74-1; 50-29-3
Publication Date
20080801
Document Type
Journal Article
Email Address
eskenazi@berkeley.edu
Funding Amount
909365
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-007400
Issue of Publication
3
ISSN
0002-9262
Source Name
American Journal of Epidemiology
State
CA; GA
Performing Organization
University of California, Berkeley
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