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Individual differences in the amount and timing of salivary melatonin secretion.

Authors
Burgess-HJ; Fogg-LF
Source
PLoS One 2008 Aug 26; 3(8):e3055
NIOSHTIC No.
20034371
Abstract
The aim of this study was to examine individual differences in a large sample of complete melatonin profiles not suppressed by light and search for possible associations between the amount and timing of melatonin secretion and a multitude of lifestyle variables. The melatonin profiles were derived from saliva samples collected every 30 minutes in dim light from 85 healthy women and 85 healthy men aged 18-45 years. There was a large individual variability in the amount of melatonin secreted with peak values ranging from 2 to 84 pg/ml. The onset of melatonin secretion ranged from 18:13 to 00:26 hours. The use of hormonal birth control, reduced levels of employment, a smaller number of days on a fixed sleep schedule, increased day length and lower weight were associated with an increased amplitude of melatonin secretion. The use of hormonal birth control, contact lenses, a younger age, and lower ratings of mania and paranoia were associated with a longer duration of melatonin secretion. An earlier occurrence of the onset of melatonin secretion was associated with an earlier wake time, more morningness and the absence of a bed partner. Lifestyle and behavioral variables were only able to explain about 15% of the individual variability in the amount of melatonin secretion, which is likely because of a substantial genetic influence on the levels of melatonin secretion.
Keywords
Sleep-disorders; Shift-work; Laboratory-testing; Lighting; Circadian-rhythms; Hormone-activity; Hormones; Age-factors; Genetic-factors; Salivary-glands; Biological-factors
Contact
Biological Rhythms Research Laboratory, Rush University Medical Center, Chicago, Illinois 60612
CODEN
POLNCL
Publication Date
20080801
Document Type
Journal Article
Email Address
Helen_J_Burgess@rush.edu
Funding Amount
846000
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-003954
Issue of Publication
8
ISSN
1932-6203
Priority Area
Work Environment and Workforce: Organization of Work
Source Name
Public Library of Science
State
IL
Performing Organization
Rush University Medical Center, Chicago, Illinois
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