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In vitro studies on the genotoxicity of 2,4-dichloro-6-nitrophenol ammonium (DCNPA) and its major metabolite.

Authors
Heng-ZC; Ong-T; Nath-J
Source
Mutat Res 1996 Jun; 368(2):149-155
NIOSHTIC No.
20034334
Abstract
2,4-dichloro-6-nitrophenol ammonium (DCNPA) is used as a herbicide. However, information on the potential health hazards of DCNPA is limited. In a previous study, we found that DCNPA is genotoxic to Bacillus subtilis and yeast. Further studies were performed to determine whether DCNPA and its major metabolite, 2,4-dichloro-6-aminophenol (DCAP), can induce reverse mutations in Salmonella, gene mutations at the HPRT locus, sister chromatid exchanges (SCEs) and micronuclei (MN) in V79 cells. Results show that DCNPA does not produce a positive response for any endpoint at concentrations tested. However, treatment of V79 cultures with DCAP caused a significant increase in SCEs and MN in a concentration-dependent manner. These results indicate that DCAP damages DNA and causes chromosomal aberrations in V79 cells. Therefore, DCNPA could pose potential health hazards to populations exposed to this herbicide.
Keywords
Mutation; Gene-mutation; Genetic-factors; Genotoxic-effects; Mutagens; Cell-damage; Cell-biology; Cell-alteration; Cell-transformation; Cellular-reactions; Chemical-properties; Chemical-reactions; Risk-factors; Health-hazards; Author Keywords: 2,4-Dichloro-6-nitrophenol ammonium; Herbicide; Ames test; Gene mutation; Sister chromatid exchange; Micronucleus assay
Contact
Genetics and Developmental Biology Program, College of Agriculture and Forestry, West Virginia University, Morgantown 26506-6108
CODEN
MUREAV
Publication Date
19960612
Document Type
Journal Article
Fiscal Year
1996
NTIS Accession No.
NTIS Price
Issue of Publication
2
ISSN
0027-5107
NIOSH Division
DRDS
Source Name
Mutation Research
State
WV
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