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COPD and occupational exposures: a case-control study.

Authors
Weinmann-S; Vollmer-WM; Breen-V; Heumann-M; Hnizdo-E; Villnave-J; Doney-B; Graziani-M; McBurnie-MA; Buist-AS
Source
J Occup Environ Med 2008 May; 50(5):561-569
NIOSHTIC No.
20034238
Abstract
Objective: Evidence demonstrates that occupational exposures are causally linked with chronic obstructive pulmonary disease (COPD). This case-control study evaluated the association between occupational exposures and prevalent COPD based on lifetime occupational history. Methods: Cases (n = 388) aged 45 years and older with COPD were compared with controls (n = 356), frequency matched on age, sex, and cigarette smoking history. Odds ratios for exposure to each of eight occupational hazard categories and three composite measures of exposure were computed using logistic regression. Results: Occupational exposures most strongly associated with COPD were diesel exhaust, irritant gases and vapors, mineral dust, and metal dust. The composite measures describing aggregate exposure to gases, vapors, solvents, or sensitizers (GVSS) and aggregate exposure to dust, GVSS, or diesel exhaust were also associated with COPD. In the small group of never-smokers, a similar pattern was evident. Conclusion: These population-based findings add to the literature linking occupational exposures to COPD.
Keywords
Respiratory-system-disorders; Pulmonary-system-disorders; Chronic-exposure; Occupational-exposure; Occupational-diseases; Case-studies; Smoking; Statistical-analysis; Diesel-exhausts; Irritant-gases; Vapors; Metal-dusts; Mineral-dusts; Organic-solvents; Organic-dusts; Organic-vapors; Gases; Dusts; Solvents; Solvent-vapors; Tobacco-smoke; Surveillance
Contact
Sheila Weinmann, PhD, Center for Health Research, Kaiser Permanente Northwest, 3800 N. Interstate Avenue, Portland, OR 97227
CODEN
JOEMFM
Publication Date
20080501
Document Type
Journal Article
Email Address
sheila.weinmann@kpchr.org
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
1076-2752
NIOSH Division
DRDS
Priority Area
Mining; Construction
Source Name
Journal of Occupational and Environmental Medicine
State
OR; WV
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