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NTP-CERHR expert panel report on the reproductive and developmental toxicity of bisphenol A.

Authors
Chapin-RE; Adams-J; Boekelheide-K; Gray-LE; Hayward-SW; Lees-PSJ; McIntyre-BS; Portier-KM; Schnorr-TM; Selevan-SG; Vandenbergh-JG; Woskie-SR
Source
Birth Defects Res B Dev Reprod Toxicol 2008 Jun; 83(3):157-395
NIOSHTIC No.
20034214
Abstract
The National Toxicology Program (NTP)1 established the NTP Center for the Evaluation of Risks to Human Reproduction (CERHR) in June 1998. The purpose of the CERHR is to provide timely, unbiased, scientifically sound evaluations of the potential for adverse effects on reproduction or development resulting from human exposures to substances in the environment. The NTPCERHR is headquartered at NIEHS, Research Triangle Park, NC, and is staffed and administered by scientists and support personnel at NIEHS. Bisphenol A is a high-production volume chemical used in the production of epoxy resins, polyester resins, polysulfone resins, polyacrylate resins, polycarbonate plastics, and flame retardants. Polycarbonate plastics are used in food and drink packaging; resins are used as lacquers to coat metal products such as food cans, bottle tops, and water supply pipes. Some polymers used in dental sealants and tooth coatings contain bisphenol A. Exposure to the general population can occur through direct contact with bisphenol A or by exposure to food or drink that has been in contact with a material containing bisphenol A. CERHR selected bisphenol A for evaluation because of (1) high production volume; (2) widespread human exposure; (3) evidence of reproductive toxicity in laboratory animal studies; and (4) public concern for possible health effects from human exposures. Relevant literature on bisphenol A was identified from searches of the PubMed (Medline) and Toxline databases through February 2007 using the term ''bisphenol'' and the bisphenol A CAS RN (80-05-7). References were also identified from databases such as REPROTOX, HSDB, IRIS, and DART, from the bibliographies of the literature reviewed, by members of the expert panel, and in public comments. CERHR convened a 12-member, independent panel of government and non-government scientists to evaluate the scientific studies on the potential reproductive and developmental hazards of bisphenol A. The expert panel met publicly on March 5-7, 2007 and August 6-8, 2007. The Expert Panel Report on Bisphenol A is intended to (1) interpret the strength of scientific evidence that bisphenol A is a reproductive or developmental toxicant based on data from in vitro, animal, or human studies; (2) assess the extent of human exposures to include the general public, occupational groups, and other subpopulations; (3) provide objective and scientifically thorough assessments of the scientific evidence that adverse reproductive and developmental health effects may be associated with such exposures; and (4) identify knowledge gaps to help establish research and testing priorities to reduce uncertainties and increase confidence in future evaluations. This report has been reviewed by members of the expert panel and by CERHR staff scientists. Copies of this report have been provided to the CERHR Core Committee and will be made available to the public for comment.
Keywords
Toxic-effects; Toxins; Toxicology; Risk-factors; Risk-analysis; Reproduction; Reproductive-system; Reproductive-hazards; Reproductive-system-disorders; Reproductive-effects; Hormone-activity; Hormones; Glycols; Foodstuff; Food; Food-additives
Contact
Michael D. Shelby, PhD, NIEHS EC-32, PO Box 12233, Research Triangle Park, NC 27709
CODEN
BDRPCU
CAS No.
80-05-7
Publication Date
20080601
Document Type
Journal Article
Email Address
shelby@niehs.nih.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
1542-9733
NIOSH Division
DSHEFS
Source Name
Birth Defects Research Part B: Developmental and Reproductive Toxicology
State
OH; CT; RI; NC; MA; MD; GA; NJ; TN
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