Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Tumor promoting or tumor suppressing of NF-kB, a matter of cell context dependency.

Authors
Chen-F; Beezhold-K; Castranova-V
Source
Int Rev Immunol 2008 Jul; 27(4):183-204
NIOSHTIC No.
20034122
Abstract
Nuclear factor-kappa B (NF-kappa B) and its activating signaling pathways are critical regulators for cell lineage development, growth, differentiation, apoptosis, and tumorigenic transformation. As one of the most important transcription factors, NF-kappa B has been implicated in the transcriptional upregulation of a number of cytokines, adhesion molecules, growth factors, oncogenes, antiapoptotic proteins, some proapoptotic factors, and even certain viral genes. The role of NF-kappa B on tumor promoting has been well-documented in the past two decades. However, during the past few years, a considerable number of studies suggested that NF-kappa B and its activating signaling molecules may act as tumor suppressors under some circumstances. Thus, it is highly possible that tumor promoting or tumor suppressing of NF-kappa B signaling is determined by the type of cells, stimuli, simultaneous or asynchronous intracellular signals, and other cellular contexts.
Keywords
Cell-biology; Cell-differentiation; Cell-function; Cell-metabolism; Cell-transformation; Cellular-function; Cellular-reactions; Nuclear-properties; Oncogenesis; Oncogenic-agents; Oncogenicity; Tumor-inhibition
Contact
Fei Chen, Pathology and Physiology Research Branch, The Health Effects Laboratory Division, National Institute for Occupational Safety and Health, Morgantown, West Virginia
CODEN
IRIMEH
Publication Date
20080701
Document Type
Journal Article
Email Address
LFD3@cdc.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0883-0185
NIOSH Division
HELD
Priority Area
Manufacturing; Mining
Source Name
International Reviews of Immunology
State
WV
TOP