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Nanomaterial labels in electrochemical immunosensors and immunoassays.

Authors
Liu-G; Lin-Y
Source
Talanta 2007 Dec; 74(3):308-317
NIOSHTIC No.
20034119
Abstract
This article reviews recent advances in nanomaterial labels in electrochemical immunosensors and immunoassays. Various nanomaterial labels are discussed, including colloidal gold/silver, semiconductor nanoparticles, and markers loaded nanocarriers (carbon nanotubes, apoferritin, silica nanoparticles, and liposome beads). The enormous signal enhancement associated with the use of nanomaterial labels and with the formation of nanomaterial-antibody-antigen assemblies provides the basis for ultrasensitive electrochemical detection of disease-related protein biomarkers, biothreat agents, or infectious agents. In general, all endeavors cited here are geared to achieve one or more of the following goals: signal amplification by several orders of magnitude, lower detection limits, and detecting multiple targets.
Keywords
Electrochemical-properties; Electrochemical-reactions; Electrochemistry; Particle-counters; Particulate-sampling-methods; Particulates; Immunochemistry; Immune-reaction; Biomarkers; Biological-agents; Biological-effects; Biological-factors; Biological-function; Biological-monitoring; Biological-systems; Nanotechnology; Author Keywords: Nanomaterials; Nanoparticles; Immunosensors; Immunoassays; Carbon Nanotubes; Biomarkers
Contact
Guodong Liu, Department of Chemistry and Molecular Biology, North Dakota State University, Fargo, ND 58105-5516
CODEN
TLNTA2
CAS No.
7440-44-0
Publication Date
20071215
Document Type
Journal Article
Email Address
guodong.liu@ndsu.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008173
Issue of Publication
3
ISSN
0039-9140
Priority Area
Agriculture, Forestry and Fishing
Source Name
Talanta
State
WA; ND
Performing Organization
Battelle Pacific Northwest Laboratories
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