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The effectiveness of N-acetyl-L-cysteine (L-NAC) in the prevention of severe noise-induced hearing loss.

Authors
Hamernik-RP; Qiu-W; Davis-B
Source
Hear Res 2008 May; 239(1-2):99-106
NIOSHTIC No.
20034117
Abstract
Three groups of chinchillas were exposed to a nonGaussian continuous broadband noise at an Leq=10 5dB SPL, 8h/d for 5d. One group (N=6) received only the noise. A second group (N=6) received the noise and was additionally treated with L-NAC (325 mg/kg, i.p.). Treatment was administered twice daily for 2d prior to exposure and for 2d following the exposure. During exposure the animals received the L-NAC just prior to and immediately after each daily exposure. The third group (N=4) was exposed to the noise and received saline injections on the same schedule as the L-NAC treated animals. Auditory evoked potential recordings from the inferior colliculus were used to estimate pure tone thresholds and surface preparations of the organ of Corti quantified the sensory cell population. In all three groups PTS exceeded 50 dB at 2.0k Hz and above with severe sensory cell loss in the basal half of the cochlea. There was no statistically significant difference among the three groups in all measures of noise-induced trauma. Treatment with L-NAC did not reduce the trauma produced by a high-level, long duration, broadband noise exposure.
Keywords
Noise; Noise-exposure; Noise-induced-hearing-loss; Hearing-loss; Animal-studies; Acoustics; Auditory-system; Cell-biology; Cell-damage; Cell-function; Cellular-reactions; Ears; Laboratory-animals
Contact
Roger P. Hamernik, Auditory Research Laboratory, 107 Beaumont Hall, State University of New York, Plattsburgh, NY 12901, USA
CODEN
HERED3
CAS No.
41575-94-4
Publication Date
20080501
Document Type
Journal Article
Email Address
roger.hamernik@plattsburgh.edu
Funding Amount
2829511
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-002317
Issue of Publication
1-2
ISSN
0378-5955
Priority Area
Construction; Manufacturing
Source Name
Hearing Research
State
NY; PA
Performing Organization
State University of New York at Buffalo, Buffalo, New York
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