Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Rheumatoid arthritis in an asbestos-exposed occupational cohort.

Authors
Sullivan-PA; Cooper-G
Source
Am J Epidemiol 2008 Jun; 167(11)(Suppl):S117
NIOSHTIC No.
20034114
Abstract
This study evaluated non-respiratory effects in a cohort of asbestos-exposed vermiculite workers. We followed 1672 white male Libby, Montana, vermiculite miners, millers, and processing workers with amphibole fiber exposure. Using the NIOSH Life Table Analysis System, age-adjusted underlying cause arthritis mortality through 2001 was compared to white men in the U.S. population. Allowing for a 15-year lag, these workers were 9.5 times (95% CI 3.1-23.5) more likely than expected to die with a diagnosis of arthritis (n 5). After death certificate review to identify any mention of rheumatoid arthritis (n 12 deaths), multiple cause mortality was evaluated using the Cox proportional hazards model. After controlling for years since hire and pack years, using age at death as the time dimension, the relative hazard ratio (HR) for rheumatoid arthritis was 1.3 (95% CI 0.8-1.9) per 100,000 fibers/cc-years. For duration, the HR was 1.05 (95% CI 0.99-1.12), suggesting a 5% increase in risk of dying with rheumatoid arthritis for each year of employment. The HR for pack-years was 1.017 (95% CI 0.998-1.036). The association with smoking was expected given previous research on rheumatoid arthritis. These findings are consistent with a recently published report of excess rheumatoid arthritis morbidity among a subset of Libby vermiculite workers (Noonan et al., 2006). Taken together, that report and the findings reported here suggest that exposure to asbestos fibers may be associated with at least one systemic autoimmune disease. Disclaimer: This abstract does not necessarily reflect EPA policy.
Keywords
Workplace-studies; Statistical-analysis; Asbestos-industry; Asbestos-mining; Asbestos-workers; Osteogenesis; Age-factors; Hazardous-materials; Milling-industry; Mine-workers; Rheumatoid-disorders
CODEN
AJEPAS
Publication Date
20080601
Document Type
Abstract
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
11
ISSN
0002-9262
NIOSH Division
DRDS
Source Name
American Journal of Epidemiology; 41st Annual Meeting Society for Epidemiologic Research Chicago, Illinois, June 24-27, 2008
State
WV
TOP