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Pulmonary effects and tissue distribution of metals after inhalation of mild steel welding fume.

Authors
Antonini-JM; Stone-S; Chen-B; Roberts-JR; Schwegler-Berry-D; Moseley-A; Donlin-M; Cumpston-J; Afshari-A; Frazer-DG
Source
Am J Respir Crit Care Med 2008 Apr; 177(Meeting Abstracts):A910
NIOSHTIC No.
20034066
Abstract
Rationale: Many welders experience bronchitis, metal fume fever, and lung function changes. The objective was to assess the effect of mild steel welding fume (MSWF) inhalation on lung injury, inflammation, defense responses, and fate of inhaled metals. Methods: Sprague-Dawley rats were exposed to MSWF at a concentration of 40 mg/m^3 x 3 hr/d x 3 or 10 d using a novel robotic welding fume generator. Controls were exposed to air. To assess lung defense responses, a group of animals were intratracheally inoculated with 5 x 10^4 Listeria monocytogenes 1 d after the last daily exposure. Welding particles were collected during exposure, and chemical composition and particle size were determined. After exposure, parameters of lung injury (lactate dehydrogenase and albumin), inflammation (PMN influx), and host defense (bacterial clearance) were measured. Also, multiple organs were recovered for metal analysis to assess fate of inhaled panicles. Results: The particles were composed primarily of Fe (80.6 %) and Mn ( 14.7 %) with a mass median aerodynamic diameter of 0.31 micro m. No significant difference was observed in lung injury or inflammation after MSWF inhalation at 1, 4, and 11 d after the last exposure. However, there were significantly more bacteria at 3 d after infection in the lungs of the animals exposed to MSWF compared to air controls. Significant elevations in lung Fe and Mn, liver Fe, and kidney Mn were observed after 10 d of exposure to MSWF compared to air. Conclusions: Acute exposure of rats to MSWF had no effect on injury and inflammation, but suppressed lung defense responses after infection. Also, metals in MSWF may translocate from the lungs to other organs, possibly causing systemic effects. Chronic inhalation studies are needed to further examine the health effects and fate of inhaled welding fume.
Keywords
Pulmonary-system-disorders; Pulmonary-disorders; Respiratory-irritants; Respiratory-system-disorders; Alveolar-cells; Lung-cells; Lung-disorders; Welders-lung; Welding-industry; Metal-compounds; Metal-fume-fever; Metallic-compounds; Dust-particles; Particulate-dust; Bacterial-infections; Inhalation-studies
CODEN
AJCMED
CAS No.
7439-89-6; 7439-96-5
Publication Date
20080401
Document Type
Abstract; Conference/Symposia Proceedings
Email Address
jga@cdc.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
ISSN
1073-449X
NIOSH Division
HELD
Priority Area
Construction; Manufacturing
Source Name
American Journal of Respiratory and Critical Care Medicine
State
WV
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