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Use of immunoassays for biomonitoring herbicides in urine.

Authors
Mastin-P; Striley-CAF; Biagini-RE
Source
Abstr Pap - Am Chem Soc 1997 Sep; 214(1):47-AGRO
NIOSHTIC No.
20034019
Abstract
Our laboratory has been experimenting with using commercially available ground water immunoassays to analyze urine samples from workers exposed to the herbicides alachlor (ALA), metolachlor(MET), atrazine (ATZ), cyanazine, and 2,4-D. Several issues related to using these kits for urinary biomonitoring have been addressed in this study, including matrix effects and cross reactivities of the kit antibodies with metabolites of the herbicides and with other chemically-related herbicides. In general, dilution of the urine has proven satisfactory in removing matrix effects for all the kits except 2,4-D. The ALA and ATZ kits showed cross-reactivities with their respective mercapturate derivatives, whereas the MET kit showed cross-reactivities with other acetanilides, but no reactivity with MET-mercapturate. These issues, along with considerations involved in determining LOD and linearity range, will be discussed. In addition, results from experiments involving direct-reading field immunoassay kits will be discussed.
Keywords
Urinalysis; Herbicides; Water-analysis; Water-sampling; Biological-monitoring; Agricultural-chemicals
CODEN
ACSRAL
Publication Date
19970907
Document Type
Abstract
Fiscal Year
1997
NTIS Accession No.
NTIS Price
ISSN
0065-7727
NIOSH Division
DBBS; DSHEFS
Source Name
Abstracts of Papers - American Chemical Society
State
OH
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