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Reduction of carcinogenic chromium(vi) on the skin of living rats.

Authors
Liu-KJ; Mader-K; Shi-X; Swartz-HM
Source
Magn Reson Med 1997 Oct; 38(4):524-526
NIOSHTIC No.
20034009
Abstract
The reduction of chromate (Cr(VI)) on the skin of living rats was investigated using the technique of in vivo electron paramagnetic resonance (EPR) spectroscopy with a surface coil resonator. Topical application of aqueous solution of Cr(VI) on the skin of rats generated the transient species, Cr(V). Partial removal of the stratum corneum increased the rates of formation and decay of Cr(V), as well as Cr(V) signal intensity. The results demonstrate that skin represents one route for chromium to enter into animals and humans. The generation of reactive Cr(V) species in the reduction of Cr(VI) by the skin may play an important role in the mechanism of Cr(VI)-induced skin cancer. These findings indicate the potential for in vivo EPR spectroscopy for studying the metabolism of paramagnetic reactive species in chemical and biochemical reactions occurring in/on the skin of both small and large animals, and possibly humans.
Keywords
Laboratory-animals; Animal-studies; Chromium-compounds; Skin-tests; Skin-exposure; Skin-absorption; Exposure-assessment; Exposure-levels; Skin-cancer; Heavy-metals; Metal-compounds; Metallic-compounds
Contact
Ke Jian Liu, Dartmouth Medical School, 7785 Remsen, Room 620, Hanover, NH 03755
CODEN
MRMEEN
CAS No.
18540-29-9; 7440-47-3
Publication Date
19971001
Document Type
Journal Article
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0740-3194
NIOSH Division
HELD
Source Name
Magnetic Resonance in Medicine
State
WV; NH
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