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Aerosolization of single-walled carbon nanotubes for an inhalation study.

Authors
Baron-PA; Deye-GJ; Chen-BT; Schwegler-Berry-DE; Shvedova-AA; Castranova-V
Source
Inhal Toxicol 2008 Jun; 20(8):751-760
NIOSHTIC No.
20034005
Abstract
Single-walled carbon nanotubes (SWCNT) are being produced in increasing quantities because of high interest in applications resulting from their unique properties. Because of potential respiratory exposures during production and handling, inhalation studies are needed to determine potential toxicity. A generation system was designed to produce respirable aerosol at 5 mg/m3 for a 1-wk animal (mouse) exposure. The starting material used in these experiments was as-produced powder from the high pressure carbon monoxide method that was sieved to number 6 mesh (< 2.3 mm). An acoustic feeder system was developed that handled the SWCNT powder without causing compaction of the material. The feed rate was adjustable, allowing output concentrations as high as 25 mg/m3. The powder particles were reduced in size using a mill that produced high shear forces, tearing the agglomerates apart. The resulting aerosol was size-separated using a settling chamber and two cyclones to produce a respirable aerosol. The mass output efficiency of the entire system for producing a respirable aerosol from bulk material was estimated to be about 10%.
Keywords
Aerosol-generators; Aerosols; Inhalation-studies; Particulates; Nanotechnology
Contact
Paul A. Baron, National Institute of Occupational Safety and Health, 4676 Columbia Parkway, Cincinnati, OH 45226
CODEN
INHTE5
Publication Date
20080601
Document Type
Journal Article
Email Address
pab2@cdc.gov
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Issue of Publication
8
ISSN
0895-8378
NIOSH Division
DART; HELD
Priority Area
Manufacturing
Source Name
Inhalation Toxicology
State
WV; OH
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