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Environmental survey of occupational exposure to aerosolized egg allergens in the egg processing industry.

Authors
Lummus-ZL; Boeniger-M; Biagini-R; Massoudi-M; Bernstein-DI
Source
J Allergy Clin Immunol 1997 Jan; 99(1)(Suppl 2):S502
NIOSHTIC No.
20033998
Abstract
Inhaled proteins arc occupational allergens that cause IgE-mcdiatcd occupational asthma (OA) in egg production workers (Ws). Raw and processed egg particles become airborne during processing. To evaluate occupational ambient exposure to aerosolized egg, we analyzed the quantity and worksitc distribution of total protein and specific egg white allergens; ovalbumin (OVA), ovomucoid (OVOM), & egg lyzozyme (LYS), at a facility with 95 exposed Ws. Aerosol exposures were monitored using 37-mm closedface cassettes with polyethylene-supported Teflon TM filters and personal sampling pumps, with air flow of 2 l/min., for an 8-hour shift. Filter protein was eluted in PBS, .05% Tween 20. pH 7.4. BCA tests (Pierce) were used to measure total protein; specific allergens were measured by competitive inhibition and sandwich EIAs. In stationary paired samples, the mean respirable/total protein ratio was 322/6(17 ug/m 3. A control referent plant showed a maximum of 41 ug/m3 protein with no detectable specific egg protein. The results indicate that OVA, which comprises 54% of egg protein was the predominant airborne antigen. Air sampling for egg protein can be useful to identify those locations where workers are exposed to high concentrations and where additional controls might be implemented.
Keywords
Sensitization; Sensitivity-testing; Occupational-exposure; Occupational-respiratory-disease; Immunological-tests; Immune-reaction; Respiratory-irritants; Respiratory-system-disorders; Pulmonary-system-disorders; Allergies; Allergic-reactions; Proteins
CODEN
JACIBY
Publication Date
19970101
Document Type
Conference/Symposia Proceedings; Abstract
Fiscal Year
1997
NTIS Accession No.
NTIS Price
Issue of Publication
1
ISSN
0091-6749
NIOSH Division
DSHEFS; DBBS
Source Name
Journal of Allergy and Clinical Immunology
State
OH
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