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Dietary restriction mitigates ozone-induced lung inflammation in rats: a role for endogenous antioxidants.

Authors
Kari-F; Hatch-G; Slade-R; Crissman-K; Simeonova-PP; Luster-M
Source
Am J Respir Cell Mol Biol 1997 Dec; 17(6):740-747
NIOSHTIC No.
20033971
Abstract
Studies were undertaken to determine whether dietary restriction protects against acute pulmonary oxidant challenge, Male F344 rats were ed NIH-31 diet either ad libitum or at restricted levels equal to 75% that of ad libitum intake. After 3 wk of dietary adaptation, animals were exposed by inhalation to 2.0 ppm ozone (O-3) for 2 h or chamber air and evaluated for cellular and biochemical indices of pulmonary toxicity. Compared to air controls, bronchoalveolar lavage fluid (BALF) from O-3 exposed ad libitum fed rats contained increased protein (145 versus 380 mu g/ml), PMN infiltration (0 versus 11%) and fibronectin (45 versus 607 U/ml). Diet restriction abrogated these indicators of pulmonary inflammation induced by ozone. Binding of O-18(3) to BALF protein and cells was significantly decreased in diet restricted rats while BALF ascorbate and glutathione levels, bill not alpha-tocopherol or urate, were elevated compared to an libitum fed rats. Taken together, these results indicate that dietary restriction affords protection against O-3-induced oxidant toxicity. Protection is mediated partially by increases in ascorbate in the fluid bathing the lung surface, thereby providing an antioxidant sink which minimizes the ability of O-3 to reach biological targets.
Keywords
Air-quality; Air-sampling; Biochemical-analysis; Inhalation-studies; Breathing; Pulmonary-disorders; Pulmonary-function; Pulmonary-system-disorders; Laboratory-animals; Laboratory-testing; Toxic-effects; Toxic-vapors; Toxins; Chemical-hypersensitivity; Chemical-properties
Contact
M Luster, NIOSH, Health Effects Research Laboratory, Toxicol & Molecular Biology Branch, 1095 Willowdale Rd, Mailstop 3014, Morgantown, WV 26505
CODEN
AJRBEL
Publication Date
19971201
Document Type
Journal Article
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
6
ISSN
1044-1549
NIOSH Division
HELD
Source Name
American Journal of Respiratory Cell and Molecular Biology
State
WV
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