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Comment on "Relative susceptibility of animals and humans to the cancer hazard posed by 2,3,7,8-tetrachlorodibenzo-p-dioxin using internal measures of dose."

Authors
Dankovic-DA; Stayner-LT
Source
Environ Sci Technol 1998 Feb; 32(4):549-550
NIOSHTIC No.
20033954
Abstract
Aylward et al. (1) are to be commended for their attempt to use empirical data to address the question of whether the carcinogenicity of TCDD in humans is quantitatively similar to that observed in animals. However, we disagree with the authors' interpretation of their results. The empirical evidence presented by Aylward et al. (1) does not lend support to the use of area under the concentration-time curve (AUC) as a dose metric for cross-species extrapolation of toxicity and does not support the authors' conclusion that "humans are much less sensitive than rats to the carcinogenic effects of TCDD". A more appropriate conclusion to draw from their analysis would be that it lends empirical support to the use of lifetime average concentration as a dose metric for cross-species scaling of TCDD carcinogenicity.
Keywords
Epidemiology; Risk-analysis; Risk-factors; Laboratory-animals; Humans; Cancer-rates; Carcinogenesis; Carcinogenicity; Carcinogens; Chemical-properties
Contact
David A. Dankovic, NIOSH, Risk Evaluation Branch, 4676 Columbia Parkway, Cincinnati, OH 45226
CODEN
ESTHAG
Publication Date
19980215
Document Type
Other
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0013-936X
NIOSH Division
EID
Source Name
Environmental Science and Technology
State
OH
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