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Efficacy of taurine based compounds as hydroxyl radical scavengers in silica induced peroxidation.

Authors
Shi-X; Flynn-DC; Porter-DW; Leonard-SS; Vallyathan-V; Castranova-V
Source
Ann Clin Lab Sci 1997 Sep; 27(5):365-374
NIOSHTIC No.
20033929
Abstract
While it is widely believed that taurine may play an important role in protecting cells against toxic injury by functioning as an antioxidant, there is a lack of evidence to support this hypothesis. In this study, electron spin resonance (ESR) was used to investigate the reaction of taurine and hypotaurine with hydroxyl radicals (.OH). The Fenton reaction (Fe(II) + H2O2-->Fe(III) + .OH + OH-) and the Cr(V)-mediated Fenton-like reaction (Cr(V) + H2O2-->Cr(VI) + .OH + OH-) were used as sources of .OH radicals. The results show that hypotaurine but not taurine effectively scavenges .OH radicals with a reaction rate constant of k = 1.6 x 10(10) M-1s-1. That is comparable with other efficient .OH radical scavengers. The effect of taurine and hypotaurine on silica-induced lipid peroxidation was evaluated using linoleic acid as a model lipid. Hypotaurine, but not taurine, caused a significant inhibition of silica-induced lipid peroxidation. The results show that hypotaurine is an excellent antioxidant and appears to have the potential for being a therapeutic agent against silica-induced lung injury.
Keywords
Free-radicals; Free-radical-generation; Cell-function; Cell-damage; Cell-biology; Cellular-reactions; Lipid-peroxidation; Lipids; Silicates; Lung-irritants; Respiratory-irritants; Antioxidants
CODEN
ACLSCP
CAS No.
14808-60-7; 107-35-7
Publication Date
19970901
Document Type
Journal Article
Fiscal Year
1997
NTIS Accession No.
NTIS Price
Issue of Publication
5
ISSN
0091-7370
NIOSH Division
HELD
Source Name
Annals of Clinical and Laboratory Science
State
WV
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