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Safety evaluation and risk assessment using immunotoxicology methods.

Authors
Dean-JH; Hincks-J; Luster-MI; Gerberick-GF; Neumann-DA; Hastings-KL
Source
Int J Toxicol 1998 May-Jun; 17(3):277-296
NIOSHTIC No.
20033917
Abstract
The field of immunotoxicity has advanced considerably in the past few years with the systematic evaluation of methods to predict immunosuppression, myelosuppression, and certain types of hypersensitivity. International interlaboratory comparisons have been conducted with methods for detecting immunosuppression (White et al., 1994) and contact hypersensitivity with good agreement (Kimber et al., 1995). The standard tier for immunotoxicity assessment, as described by the National Toxicology Program (Luster et al., 1988), and methods suggested by the GECD 407 Guideline (van Loveren et al., 1996) are considered useful in both the mouse and rat. Likewise, these new methods have been introduced and evaluated in the safety assessment of new pharmaceuticals and chemicals by some companies. Most of the methods developed have been drawn from our experience in clinical immunology and an improved understanding of the immune system through advances in molecular biology and basic immunology. There is still work to be done to better document the correlation between animal immunotoxicity results and adverse effects in humans following exposure to chemicals in our environment, and to define predictive methods for evaluating the potential of a drug to induce allergy and autoimmunity, still a significant unpredicted clinical finding.
Keywords
Risk-factors; Safety-measures; Safety-practices; Safety-research; Immune-reaction; Immunodiagnosis; Immunology; Toxic-effects; Toxicology
Contact
JH Dean, Sanofi Res, Sanofi Pharmaceut Inc, 9 Great Valley Pkwy,POB 3026, Malvern, PA 1935
CODEN
IJTOFN
Publication Date
19980501
Document Type
Journal Article
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
3
ISSN
1091-5818
NIOSH Division
HELD
Source Name
International Journal of Toxicology
State
WV; PA; OH; MD; DC
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