Skip directly to search Skip directly to A to Z list Skip directly to page options Skip directly to site content

NIOSHTIC-2 Publications Search

Search Results

Temporal variation in the association between benzene and leukemia mortality.

Authors
Richardson-DB
Source
Environ Health Perspect 2008 Mar; 116(3):370-374
NIOSHTIC No.
20033895
Abstract
BACKGROUND: Benzene is a human carcinogen. Exposure to benzene occurs in occupational and environmental settings. OBJECTIVE: I evaluated variation in benzene-related leukemia with age at exposure and time since exposure. METHODS: I evaluated data from a cohort of 1,845 rubber hydrochloride workers. Benzene exposure-leukemia mortality trends were estimated by applying proportional hazards regression methods. Temporal variation in the impact of benzene on leukemia rates was assessed via exposure time windows and fitting of a multistage cancer model. RESULTS: The association between leukemia mortality and benzene exposures was of greatest magnitude in the 10 years immediately after exposure [relative rate (RR) at 10 ppm-years = 1.19; 95% confidence interval (CI), 1.10-1.29]; the association was of smaller magnitude in the period 10 to < 20 years after exposure (RR at 10 ppm-years = 1.05; 95% CI, 0.97-1.13); and there was no evidence of association > or = 20 years after exposure. Leukemia was more strongly associated with benzene exposures accrued at > or = 45 years of age (RR at 10 ppm-years = 1.11; 95% CI, 1.04-1.17) than with exposures accrued at younger ages (RR at 10 ppm-years = 1.01; 95% CI, 0.92-1.09). Jointly, these temporal effects can be efficiently modeled as a multistage process in which benzene exposure affects the penultimate stage in disease induction. CONCLUSIONS: Further attention should be given to evaluating the susceptibility of older workers to benzene-induced leukemia.
Keywords
Risk-factors; Risk-analysis; Mortality-data; Occupational-diseases; Diseases; Occupational-exposure; Chemical-hypersensitivity; Cancer-rates; Age-factors; Solvent-vapors; Solvents; Carcinogens; Benzenes; Blood-disorders
Contact
David B. Richardson, Richardson, Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599
CODEN
EVHPAZ
CAS No.
71-43-2
Publication Date
20080301
Document Type
Journal Article
Email Address
david.richardson@unc.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-K01-OH-008635
Issue of Publication
3
ISSN
0091-6765
Priority Area
Manufacturing
Source Name
Environmental Health Perspectives
State
NC
Performing Organization
University of North Carolina, Chapel Hill
TOP