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Exposure to dioxin and nonneoplastic mortality in the expanded IARC international cohort study of phenoxy herbicide and chlorophenol production workers and sprayers.

Authors
Vena-J; Boffetta-P; Becher-H; Benn-T; Bueno-De-Mesquita-HB; Coggon-D; Colin-D; Flesch-Janys-D; Green-L; Kauppinen-T; Littorin-N; Lynge-E; Mathews-JD; Neuberger-M; Pearce-N; Pesatori-AC; Saracci-R; Steenland-K; Kogevinas-M
Source
Environ Health Perspect 1998 Apr; 106(4)(Suppl 2):645-653
NIOSHTIC No.
20033876
Abstract
The authors studied noncancer mortality among phenoxyacid herbicide and chlorophenol production workers and sprayers included in an international study comprising 36 cohorts from 12 countries followed from 1939 to 1992. Exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin or higher chlorinated dioxins (TCDD/HCD) was discerned from job records and company questionnaires with validation by biologic and environmental measures. Standard mortality ratio analyses suggested a moderate healthy worker effect for all circulatory diseases, especially ischemic heart disease, among both those exposed and those not exposed to TCDD/HCD. In Poisson regression analyses, exposure to TCDD/HCD was not associated with increased mortality from cerebrovascular disease. However, an increased risk for circulatory disease, especially ischemic heart disease (rate ratio [RR] 1.67, 95% confidence interval [CI] 1.23-2.26) and possibly diabetes (RR 2.25, 95% CI 0.53-9.50), was present among TCDD/HCD-exposed workers. Risks tended to be higher 10 to 19 years after first exposure and for those exposed for a duration of 10 to 19 years. Mortality from suicide was comparable to that for the general population for all workers exposed to herbicides or chlorophenols and was associated with short latency and duration of exposure. More refined investigations of the ischemic heart disease and TCDD/HCD exposure association are warranted.
Keywords
Hepatotoxins; Fungicides; Chemical-hypersensitivity; Biological-factors; Environmental-exposure; Cerebrovascular-system-disorders; Cardiovascular-system-disorders; Statistical-analysis; Herbicides; Pesticide-industry; Pesticides
CODEN
EVHPAZ
CAS No.
1746-01-6
Publication Date
19980401
Document Type
Journal Article
Email Address
boffetta@iarc.fr
Fiscal Year
1998
NTIS Accession No.
NTIS Price
Issue of Publication
4
ISSN
0091-6765
NIOSH Division
DSHEFS
Source Name
Environmental Health Perspectives
State
OH
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