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Regulation of vascular reactivity in scleroderma: new insights into Raynaud's phenomenon.

Authors
Flavahan-NA
Source
Rheum Dis Clin North Am 2008 Feb; 34(1):81-87
NIOSHTIC No.
20033860
Abstract
Because of the role of the RhoA/Rho kinase (ROCK) pathway in regulating numerous pathologic processes including vasoconstriction, vascular remodeling, and fibrosis, ROCK inhibitors may be especially beneficial in treating Raynaud's phenomenon and scleroderma.
Keywords
Muscle-cells; Proteins; Enzymes; Hormone-activity; Hormones; Vasoactive-agents; Blood-vessels; Skin-exposure; Skin-protection; Vibration-disease
Contact
Nicholas A. Flavahan PhD, Department of Anesthesiology and Critical Care Medicine, Johns Hopkins University, Ross Research Building R370, 720 Rutland Avenue, Baltimore, MD 21205
CODEN
RDCAEK
Publication Date
20080201
Document Type
Journal Article
Email Address
nflavah1@jhmi.edu
Funding Type
Grant
Fiscal Year
2008
NTIS Accession No.
NTIS Price
Identifying No.
Grant-Number-R01-OH-008531
Issue of Publication
1
ISSN
0889-857X
Source Name
Rheumatic Diseases Clinics of North America
State
MD
Performing Organization
Jonhs Hopkins University
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