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Biomarker and metabolite analysis by HPLC/MS.

Authors
B'Hymer-C; Cheever-KL
Source
Encyclopedia of Chromatography, 3rd Edition. Cazes J, ed., Boca Raton, FL: Taylor and Francis, Online-supplement, 2008 Jan; :1-10
NIOSHTIC No.
20033732
Abstract
High-performance liquid chromatography-mass spectrometry (HPLC-MS) is a powerful analytical technique widely used in recent years for the analysis of biomarkers and metabolites. Biomarker determination and quantification, whether metabolic or adducted biomolecules, are commonly used to evaluate exposure and support biomonitoring research, especially in the area of occupational exposure and health. Some of the common problems and strategies of HPLC-MS biomarker analysis involve matrix effects, the use of isotope labeled internal standard compounds and sample clean-up; usually all of these factors must be evaluated within the development phase of an analysis procedure. Specific examples of biomarker analysis using HPLC-MS include acrylamide, aromatic compounds, and 1-bromopropane, and these examples are discussed in detail.
Keywords
Analytical-processes; Analytical-chemistry; Analytical-methods; Biomarkers; Sampling-methods; Sample-preparation
CAS No.
79-06-1; 106-94-5
Publication Date
20080115
Document Type
Book or book chapter
Editors
Cazes-J
Fiscal Year
2008
NTIS Accession No.
NTIS Price
ISBN No.
9780824727888
NIOSH Division
DART
Priority Area
Healthcare and Social Assistance; Services
Source Name
Encyclopedia of Chromatography, 3rd Edition
State
OH
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